Recombinant Human Ribonucleotide Reductase M2, His-tagged

• Cat.No.: RRM2-705H
• Product Overview: Recombinant human RRM2 protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques.MW = 47.0 kDa (409aa).

Specification

• Cat. No.: RRM2-705H
• Description: RRM2, also known as ribonucleotide reductase M2, is an enzyme that catalyzes the formation of deoxyribonucleotides from ribonucleotides. This protein plays a critical role in regulating the total rate of DNA synthesis so that DNA to cell mass is maintained at a constant ratio during cell division and DNA repair.
• Source: E.coli.
• Form: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol 0.1M NaCl.
• Purity: > 85% by SDS – PAGE.
• Concentration: 1.0 mg/ml (determined by Bradford assay).
• Sequences Of Amino Acids: MGSSHHHHHH SSGLVPRGSH MLSLRVPLAP ITDPQQLQLS PLKGLSLVDK ENTPPALSGT RVLASKTARR IFQEPTEPKT KAAAPGVEDE PLLRENPRRF VIFPIEYHDI WQMYKKAEAS FWTAEEVDLS KDIQHWESLK PEERYFISHV LAFFAASDGI VNENLVERFS QEVQITEARC FYGFQIAMEN IHSEMYSLLI DTYIKDPKER EFLFNAIETM PCVKKKADWA LRWIGDKEAT YGERVVAFAA VEGIFFSGSF ASIFWLKKRG LMPGLTFSNE LISRDEGLHC DFACLMFKHL VHKPSEERVR EIIINAVRIE QEFLTEALPV KLIGMNCTLM KQYIEFVADR LMLELGFSKV FRVENPFDFM ENISLEGKTN FFEKRVGEYQ RMGVMSSPTE NSFTLDADF.
• Storage: can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: RRM2 ribonucleotide reductase M2 [ Homo sapiens ]
• Synonyms: ribonucleotide reductase M2; R2; RR2; RR2M; RRM2; ribonucleoside-diphosphate reductase subunit M2; OTTHUMP00000115511; OTTHUMP00000214026; ribonucleotide reductase small chain; ribonucleotide reductase small subunit; ribonucleotide reductase M2 polypeptide;Ribonucleotide reductase small chain; Ribonucleotide reductase small subunit; EC 1.17.4.1
• Gene ID: 6241
• mRNA Refseq: NM_001034
• Protein Refseq: NP_001025
• MIM: 180390
• UniProt ID: P31350
• Chromosome Location: 2p25-p24
• Pathway: Glutathione metabolism; Metabolic pathways; Purine metabolism; Pyrimidine metabolism; p53 signaling pathway; Cell Cycle, Mitotic; Metabolism of nucleotides
• Function: class I ribonucleotide reductase activity; oxidoreductase activity; protein binding; ribonucleoside-diphosphate reductase activity; transition metal ion binding

Reviews

05/14/2022

The professional gave me a detailed description of the RRM2 protein so that I could understand its biochemical properties.

03/31/2021

Smooth communication and timely shipment, allowing my experiment to be implemented as soon as possible.

11/20/2020

Cheap price, high quality products, worth buying again!

Q&As

What diseases has RRM2 been associated with the study of?

RRM2 has been associated with studies of liver, lung, and breast cancers.

How is RRM2 related to tumor development?

Elevated expression of RRM2 in some malignant tumors promotes tumor cell proliferation and immune escape, leading to malignant tumor progression.

What is the function of RRM2?

RRM2, which catalyzes the formation of deoxyribonucleotides from ribonucleotides, is involved in processes such as DNA repair and the cell cycle.

What is the relationship between RRM2 and ANXA1?

RRM2 interacts with ANXA1.

What is the relationship between RRM2 and RRM2B?

Both RRM2 and RRM2B are two small subunits of RR.