Recombinant Human Ribonucleotide Reductase M2, T7-tagged

• Cat.No.: RRM2-820H
• Product Overview: Recombinant RRM2 protein, fused to T7-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques, 44878Da (389aa).

Specification

• Cat. No.: RRM2-820H
• Description: Ribonucleoside-diphosphate reductase subunit M2, also known as ribonucleotide reductase small subunit, is anenzymethat in humans is encoded by the RRM2gene.
• Sequences of amino acids: MLSLRVPLP ITDPQQLQLS PLKGLSLVDK ENTPPALSGT RVLASKTARR IFQEPTEPKT KAAAPGVEDE PLLRENPRRF VIFPIEYHDI WQMYKKAEAS FWTAEEVDLS KDIQHWESLK PEERYEISHV LAFFAASDGI VNENLVERFS QEVQITEARC FYGFQIAMEN IHSEMYSLLI DTYIKDPKER EFLFNAIETM PCVKKKADWA LRWIGDKEAT YGERVVAFAA VEGIFFSGSF ASIFWLKKRG LMPGLTFSNE LISRDEGLHC DFACLMFKHL VHKPSEERVR EIIINAVRIE QEELTEALPV KLIGMNCTLM KQYIEFVADR LMLELGFSKV FRVENPFDFM ENISLEGKTN FFEKRVGEYQ RMGVMSSPTE NSFTLDADF
• Formulation: 10 mM Tris. pH 8.0. 0.1% Triton X-100. 0.002% NaN3. 10mM DTT
• Clonality: N/A
• Purity: 95% by SDS - PAGE
• Applications: MS. SDS

Gene Information

• Gene Name: RRM2 ribonucleotide reductase M2 [Homo sapiens]
• Synonyms: RRM2; RR2M; RR2; R2; EC 1.17.4.1; ribonucleotide reductase M2; ribonucleotide reductase M2 polypeptide; ribonucleoside-diphosphate reductase subunit M2; Ribonucleotide reductase small chain; Ribonucleotide reductase small subunit; OTTHUMP00000115511; OTTHUMP00000214026
• Gene ID: 6241
• mRNA Refseq: NM_001034
• Protein Refseq: NP_001025
• MIM: 180390
• UniProt ID: P31350
• Chromosome Location: 2P25-P24
• Pathway: Glutathione metabolism; Metabolic pathways; Purine metabolism; Pyrimidine metabolism; p53 signaling pathway
• Function: Oxidoreductase activity; protein binding; ribonucleoside-diphosphate reductase activity; ribonucleoside-diposphate reductase activity; transition metal ion binding

Reviews

05/14/2022

The professional gave me a detailed description of the RRM2 protein so that I could understand its biochemical properties.

03/31/2021

Smooth communication and timely shipment, allowing my experiment to be implemented as soon as possible.

11/20/2020

Cheap price, high quality products, worth buying again!

Q&As

What diseases has RRM2 been associated with the study of?

RRM2 has been associated with studies of liver, lung, and breast cancers.

How is RRM2 related to tumor development?

Elevated expression of RRM2 in some malignant tumors promotes tumor cell proliferation and immune escape, leading to malignant tumor progression.

What is the function of RRM2?

RRM2, which catalyzes the formation of deoxyribonucleotides from ribonucleotides, is involved in processes such as DNA repair and the cell cycle.

What is the relationship between RRM2 and ANXA1?

RRM2 interacts with ANXA1.

What is the relationship between RRM2 and RRM2B?

Both RRM2 and RRM2B are two small subunits of RR.