Recombinant Human RIPK2, GST-tagged, Active

• Cat.No.: RIPK2-418H
• Product Overview: Recombinant human RIPK2 (1-299) was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW=59kDa.

Specification

• Cat. No.: RIPK2-418H
• Description: RIPK2 (RIP2; RICK) is a death domain-containing protein kinase encoding a predicted 540-amino acid protein which contains an N-terminal serine/threonine kinase catalytic domain and a C-terminal caspase activation and recruitment domain. RIPK2 is thought to regulate apoptosis induced by the FAS receptor pathway. RIPK2 has been shown to specifically interact with the CARD of ICE/caspase-1 and this interaction correlates with the processing of pro-caspase-1 and the formation of the active caspase-1 p20.
• Source: Sf9 insect cells using baculovirus.
• Sequence: 1-299.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: RIPK2 receptor-interacting serine-threonine kinase 2 [ Homo sapiens ]
• Synonyms: RIPK2; receptor-interacting serine-threonine kinase 2; CARD-carrying kinase; CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase; growth-inhibiting gene 30; receptor interacting protein 2; receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase; CCK; RICK; RIP2; CARD3; GIG30; CARDIAK; EC 2.7.11.1
• Gene ID: 8767
• mRNA Refseq: NM_003821
• Protein Refseq: NP_003812
• MIM: 603455
• UniProt ID: O43353
• Chromosome Location: 8q21
• Pathway: NOD-like receptor signaling pathway; Neurotrophin signaling pathway; Signaling in Immune system; Signalling by NGF
• Function: ATP binding; CARD domain binding; LIM domain binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; signal transducer activity; transferase activity

Reviews

12/13/2019

Precise mass spectrometry analysis, key for our proteomics investigations.

04/07/2019

Dependable protein purification, consistently delivers high yield and purity.

11/23/2018

Great antibody validation, enhances our immunoprecipitation success.

Q&As

What role does RIPK2 play in the inflammatory response, particularly in the context of autoimmune diseases?

RIPK2 plays a significant role in driving inflammatory responses, implicated in autoimmune disease mechanisms.

How does RIPK2 mediate signal transduction in the NOD1 and NOD2 pathways involved in innate immunity?

RIPK2 is crucial in NOD1/NOD2 signaling, activating innate immune responses against microbial intrusions.

How do alterations in RIPK2 expression or signaling affect cancer development and progression?

Changes in RIPK2 signaling can impact cancer development, influencing tumor cell survival and immune interactions.

How does RIPK2 contribute to the regulation of NF-κB activation and cytokine production?

RIPK2 regulates NF-κB activation and cytokine production, crucial for immune response and inflammation.

What are the mechanisms by which RIPK2 modulates the host defense against bacterial pathogens?

RIPK2 modulates defense mechanisms against bacterial pathogens, coordinating immune signaling and responses.

How does RIPK2 influence cell survival and apoptosis, especially under conditions of stress or infection?

RIPK2 influences cell survival and apoptosis decisions, particularly in response to stress or microbial infection.

What is the impact of RIPK2 dysregulation on the development and progression of inflammatory bowel disease (IBD)?

Dysregulation of RIPK2 is linked to IBD, affecting intestinal inflammation and immune responses.