Recombinant Human RLN2

• Cat.No.: RLN2-30491TH
• Product Overview: Full length human recombinant Relaxin 2.

Specification

• Description: Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In the human there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3. RLN1 and RLN2 share high sequence homology. The active form of the encoded protein consists of an A chain and a B chain but their cleavage sites are not definitely described yet. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. There are two alternatively spliced transcript variants encoding different isoforms described for this gene.
• Source: E. coli
• Form: Lyophilised:Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex.
• Purity: >95% by SDS-PAGE
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequences of amino acids: A-Chain: QLYSALANKC CHVGCTKRSL ARFCB-Chain: DSWMEEVIKL CGRELVRAQI AICGMSTWS

Gene Information

• Gene Name: RLN2 relaxin 2 [ Homo sapiens ]
• Official Symbol: RLN2
• Synonyms: RLN2; relaxin 2; relaxin 2 (H2); prorelaxin H2; bA12D24.1.1; bA12D24.1.2; H2; relaxin H2; relaxin; ovarian; of pregnancy; RLXH2
• Gene ID: 6019
• mRNA Refseq: NM_005059
• Protein Refseq: NP_005050
• MIM: 179740
• Uniprot ID: P04090
• Chromosome Location: 9pter-q12
• Pathway: Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; Peptide ligand-binding receptors, organism-specific biosystem
• Function: hormone activity

Reviews

01/09/2021

Superior quality—this protein is a must-have in our lab for consistent outcomes.

04/24/2020

The quality control is evident in the data precision we achieve.

10/14/2019

Fast delivery! Got this product promptly, no delays, intact packaging.

Q&As

What are the molecular mechanisms by which RLN-2 induces vasodilation in blood vessels?

RLN-2 induces vasodilation by activating nitric oxide (NO) signaling pathways, promoting smooth muscle relaxation and increased blood flow.

How does RLN-2 interact with the immune system, and what are its immunomodulatory effects?

RLN-2 has immunomodulatory effects, influencing cytokine production, immune cell migration, and contributing to the regulation of inflammatory responses.

Can you elaborate on the molecular basis of RLN-2's anti-fibrotic effects in various tissues?

RLN-2 exerts anti-fibrotic effects by inhibiting myofibroblast differentiation, reducing collagen deposition, and modulating fibrotic signaling pathways.

How does RLN-2 influence collagen synthesis and degradation in connective tissues?

RLN-2 inhibits collagen synthesis and enhances collagen degradation by modulating the activity of enzymes involved in collagen turnover.

How does RLN-2 influence extracellular matrix remodeling, and what enzymes are involved in this process?

RLN-2 promotes extracellular matrix remodeling by upregulating matrix metalloproteinases (MMPs) and inhibiting tissue inhibitors of metalloproteinases (TIMPs).