Recombinant Human ROCK1 protein, Flag-tagged, Biotinylated

• Cat.No.: ROCK1-76H
• Product Overview: Recombinant Human ROCK1, catalytic domain [1-477 amino acids of accession number NP_005397.1] fused with DYKDDDDK tag at N-terminal was expressed in insect cell and biotinylated.

Specification

• Source: Insect cell
• Species: Human
• Tag: Flag
• Form: 50 mM Tris-HCl, 150 mM NaCl, 0.05% Brij35, 1 mM DTT, 10% glycerol, pH7.5
• Molecular Mass: 59 kDa
• Purity: >90% as determined by SDS-PAGE and CBB staining
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.

Gene Information

• Gene Name: ROCK1 Rho-associated, coiled-coil containing protein kinase 1 [ Homo sapiens ]
• Official Symbol: ROCK1
• Synonyms: ROCK1; p160ROCK; p160-ROCK; Rho kinase; p160 ROCK-1; renal carcinoma antigen NY-REN-35; ROCK-I; P160ROCK; PRO0435
• Gene ID: 6093
• mRNA Refseq: NM_005406
• Protein Refseq: NP_005397
• MIM: 601702
• UniProt ID: Q13464
• Chromosome Location: 18q11.2
• Pathway: Apoptosis, organism-specific biosystem; Apoptotic cleavage of cellular proteins, organism-specific biosystem; Apoptotic executionphase, organism-specific biosystem; Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Axon guidance, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem
• Function: ATP binding; GTP-Rho binding; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity

Reviews

08/20/2022

Reliable protein crystallization services, consistently delivers exceptional results.

03/06/2022

Accurate protein structural characterization, vital for our investigations.

07/14/2021

High-quality protein sequencing, an essential tool in our lab.

Q&As

What role does ROCK1 play in vascular tone regulation and cardiovascular health?

ROCK1 plays a significant role in vascular tone regulation, impacting blood pressure and cardiovascular function.

What are the mechanisms by which ROCK1 modulates inflammatory responses in the body?

ROCK1 regulates inflammatory processes, influencing immune cell activity and inflammation.

What is the impact of ROCK1 on cancer cell invasion, metastasis, and tumor progression?

ROCK1 influences cancer progression, particularly in aspects of cell invasion, metastasis, and tumor growth.

How does ROCK1 (Rho-Associated Coiled-Coil Containing Protein Kinase 1) regulate cytoskeletal dynamics and cell motility?

ROCK1 controls cytoskeletal rearrangements, crucial for cell shape, movement, and division.

How does ROCK1 contribute to the pathogenesis of neurological disorders, such as Alzheimer's disease?

ROCK1 is involved in neurological disorders by affecting neuronal cytoskeletal dynamics and synaptic function.

How does ROCK1 influence the process of apoptosis and cell survival?

ROCK1 modulates apoptosis, playing a role in determining cell survival or programmed cell death.

How do alterations in ROCK1 expression or activity affect tissue remodeling and fibrosis?

Changes in ROCK1 activity impact tissue remodeling and fibrosis, affecting wound healing and disease progression.