Recombinant Human ROCK1 protein, GST-tagged

• Cat.No.: ROCK1-1794H
• Product Overview: Recombinant Human ROCK1 protein(401-710 aa), fused to GST tag, was expressed in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: GST
• Form: The purified protein was Lyophilized from sterile PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8.). 5 % trehalose and 5 % mannitol are added as protectant before lyophilization. The elution buffer contain 100mM GSH.
• Protein length: 401-710 aa
• AA Sequence: SNRRYLSSANPNDNRTSSNADKSLQ ESLQKTIYKLEEQLHNEMQLKDEME QKCRTSNIKLDKIMKELDEEGNQRR NLESTVSQIEKEKMLLQHRINEYQR KAEQENEKRRNVENEVSTLKNQLED LKKVSQNSQLANEKLSQLQKQLEEA NDLLRTESDTAVRLRKSHTEMSKSI SQLESLNRELQERNRILENSKSQTD KDYYQLQAILEAERRDRGHDSEMIG DLQARITSLQEEVKHLKHNLEKVEG ERKEAQDMLNHSEKEKNNLEIDLNY KLKSLQQRLEQEVNEHKVTKARLTD KHQSIEEAKS
• Purity: 95%, by SDS-PAGE with Coomassie Brilliant Blue staining.
• Storage: Short-term storage: Store at 2-8°C for (1-2 weeks).
  Long-term storage: Aliquot and store at -20°C to -80°C for up to 3 months, buffer containing 50% glycerol is recommended for reconstitution. Avoid repeat freeze-thaw cycles.
• Reconstitution: Reconstitute at 0.25 µg/μl in 200 μl sterile water for short-term storage.
  Reconstitution with 200 μl 50% glycerol solution is recommended for longer term storage.

Gene Information

• Gene Name: ROCK1 Rho-associated, coiled-coil containing protein kinase 1 [ Homo sapiens ]
• Official Symbol: ROCK1
• Synonyms: ROCK1; Rho-associated, coiled-coil containing protein kinase 1; rho-associated protein kinase 1; p160ROCK; p160-ROCK; Rho kinase; p160 ROCK-1; renal carcinoma antigen NY-REN-35; rho-associated, coiled-coil-containing protein kinase 1; rho-associated, coiled-coil-containing protein kinase I; ROCK-I; P160ROCK; PRO0435; MGC43611; MGC131603
• Gene ID: 6093
• mRNA Refseq: NM_005406
• Protein Refseq: NP_005397
• MIM: 601702
• UniProt ID: Q13464

Reviews

08/20/2022

Reliable protein crystallization services, consistently delivers exceptional results.

03/06/2022

Accurate protein structural characterization, vital for our investigations.

07/14/2021

High-quality protein sequencing, an essential tool in our lab.

Q&As

What role does ROCK1 play in vascular tone regulation and cardiovascular health?

ROCK1 plays a significant role in vascular tone regulation, impacting blood pressure and cardiovascular function.

What are the mechanisms by which ROCK1 modulates inflammatory responses in the body?

ROCK1 regulates inflammatory processes, influencing immune cell activity and inflammation.

What is the impact of ROCK1 on cancer cell invasion, metastasis, and tumor progression?

ROCK1 influences cancer progression, particularly in aspects of cell invasion, metastasis, and tumor growth.

How does ROCK1 (Rho-Associated Coiled-Coil Containing Protein Kinase 1) regulate cytoskeletal dynamics and cell motility?

ROCK1 controls cytoskeletal rearrangements, crucial for cell shape, movement, and division.

How does ROCK1 contribute to the pathogenesis of neurological disorders, such as Alzheimer's disease?

ROCK1 is involved in neurological disorders by affecting neuronal cytoskeletal dynamics and synaptic function.

How does ROCK1 influence the process of apoptosis and cell survival?

ROCK1 modulates apoptosis, playing a role in determining cell survival or programmed cell death.

How do alterations in ROCK1 expression or activity affect tissue remodeling and fibrosis?

Changes in ROCK1 activity impact tissue remodeling and fibrosis, affecting wound healing and disease progression.