Recombinant Human RPA2 protein, His-tagged

• Cat.No.: RPA2-3892H
• Product Overview: Recombinant Human RPA2 protein(80-270 aa), fused to His tag, was expressed in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: His
• Form: The purified protein was Lyophilized from sterile PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH7.4). 5 % trehalose and 5 % mannitol are added as protectant before lyophilization. The elution buffer contain 300mM imidazole.
• Protein Length: 80-270 aa
• AA Sequence: IRHAEKAPTNIVYKIDDMTAAPMDV RQWVDTDDTSSENTVVPPETYVKVA GHLRSFQNKKSLVAFKIMPLEDMNE FTTHILEVINAHMVLSKANSQPSAG RAPISNPGMSEAGNFGGNSFMPANG LTVAQNQVLNLIKACPRPEGLNFQD LKNQLKHMSVSSIKQAVDFLSNEGH IYSTVDDDHFKSTDAE
• Purity: 95%, by SDS-PAGE with Coomassie Brilliant Blue staining.
• Storage: Short-term storage: Store at 2-8°C for (1-2 weeks).
  Long-term storage: Aliquot and store at -20°C to -80°C for up to 3 months, buffer containing 50% glycerol is recommended for reconstitution. Avoid repeat freeze-thaw cycles.
• Reconstitution: Reconstitute at 0.25 µg/μl in 200 μl sterile water for short-term storage.
  Reconstitution with 200 μl 50% glycerol solution is recommended for longer term storage.

Gene Information

• Gene Name: RPA2 replication protein A2, 32kDa [ Homo sapiens ]
• Official Symbol: RPA2
• Synonyms: RPA2; replication protein A2, 32kDa; replication protein A2 (32kD); replication protein A 32 kDa subunit; RP-A p32; RP-A p34; RF-A protein 2; replication factor A protein 2; replication protein A 34 kDa subunit; REPA2; RPA32
• Gene ID: 6118
• mRNA Refseq: NM_002946
• Protein Refseq: NP_002937
• MIM: 179836
• UniProt ID: P15927

Reviews

12/21/2020

This commitment ensures that I have access to the most advanced and reliable protein available, enhancing the integrity and impact of my experiments.

03/30/2020

The RPA2 protein exhibits exceptional quality, making it an ideal choice to meet my experimental requirements.

07/19/2018

the manufacturer's customer-centric approach highlights their focus on ensuring my satisfaction.

Q&As

How might RPA2 be targeted for cancer therapy?

Targeting RPA2 with specific inhibitors could disrupt DNA repair mechanisms in cancer cells, rendering them more susceptible to treatments like chemotherapy or radiation therapy.

How does RPA2 contribute to the maintenance of telomeres?

RPA2 participates in the protection and maintenance of telomeres, the protective caps at the end of chromosomes, thereby contributing to cellular longevity and genomic stability.

Are there any known side effects or challenges associated with targeting RPA2 in therapy?

Targeting RPA2 in therapy may pose challenges, as its essential role in normal cellular processes raises concerns about potential side effects. Careful modulation is crucial.

Can RPA2 be targeted for therapeutic purposes beyond cancer treatment?

Yes, exploring RPA2 as a therapeutic target extends to conditions where genomic stability is compromised, such as certain genetic disorders and autoimmune diseases.

Are there any ongoing clinical trials involving RPA2 in cancer treatment?

Information about specific clinical trials should be checked, but the potential use of RPA2 as a target for cancer therapy is an area of active research.