Recombinant Human RPS6KA1 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: RPS6KA1-4414H
• Product Overview: RPS6KA1 MS Standard C13 and N15-labeled recombinant protein (NP_002944) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 82.7 kDa
• AA Sequence: MPLAQLKEPWPLMELVPLDPENGQT SGEEAGLQPSKDEGVLKEISITHHV KAGSEKADPSHFELLKVLGQGSFGK VFLVRKVTRPDSGHLYAMKVLKKAT LKVRDRVRTKMERDILADVNHPFVV KLHYAFQTEGKLYLILDFLRGGDLF TRLSKEVMFTEEDVKFYLAELALGL DHLHSLGIIYRDLKPENILLDEEGH IKLTDFGLSKEAIDHEKKAYSFCGT VEYMAPEVVNRQGHSHSADWWSYGV LMFEMLTGSLPFQGKDRKETMTLIL KAKLGMPQFLSTEAQSLLRALFKRN PANRLGSGPDGAEEIKRHVFYSTID WNKLYRREIKPPFKPAVAQPDDTFY FDTEFTSRTPKDSPGIPPSAGAHQL FRGFSFVATGLMEDDGKPRAPQAPL HSVVQQLHGKNLVFSDGYVVKETIG VGSYSECKRCVHKATNMEYAVKVID KSKRDPSEEIEILLRYGQHPNIITL KDVYDDGKHVYLVTELMRGGELLDK ILRQKFFSEREASFVLHTIGKTVEY LHSQGVVHRDLKPSNILYVDESGNP ECLRICDFGFAKQLRAENGLLMTPC YTANFVAPEVLKRQGYDEGCDIWSL GILLYTMLAGYTPFANGPSDTPEEI LTRIGSGKFTLSGGNWNTVSETAKD LVSKMLHVDPHQRLTAKQVLQHPWV TQKDKLPQSQLSHQDLQLVKGAMAA TYSALNSSKPTPQLKPIESSILAQR RVRKLPSTTLTRTRPLEQKLISEED LAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: RPS6KA1 ribosomal protein S6 kinase A1 [ Homo sapiens (human) ]
• Official Symbol: RPS6KA1
• Synonyms: RPS6KA1; ribosomal protein S6 kinase, 90kDa, polypeptide 1; ribosomal protein S6 kinase, 90kD, polypeptide 1; ribosomal protein S6 kinase alpha-1; HU 1; RSK; RSK1; RSK-1; p90S6K; p90RSK1; p90-RSK 1; MAPKAPK-1a; S6K-alpha 1; S6K-alpha-1; MAPKAP kinase 1a; ribosomal S6 kinase 1; MAPK-activated protein kinase 1a; ribosomal protein S6 kinase alpha 1; 90 kDa ribosomal protein S6 kinase 1; MAP kinase-activated protein kinase 1a; dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1); HU-1; MAPKAPK1A
• Gene ID: 6195
• mRNA Refseq: NM_002953
• Protein Refseq: NP_002944
• MIM: 601684
• UniProt ID: Q15418

Reviews

07/10/2022

Exceptional protein purification, highly recommended for research.

06/02/2022

Dependable mass spectrometry analysis; enhances our proteomics research.

05/26/2020

Quick and precise protein expression, a valuable service.

Q&As

What is the impact of RPS6KA1 dysregulation on metabolic disorders, such as diabetes and obesity?

Dysregulation of RPS6KA1 impacts metabolic processes, influencing conditions like diabetes and obesity.

What are the mechanisms by which RPS6KA1 modulates the cell cycle and apoptosis?

RPS6KA1 modulates the cell cycle and apoptosis, playing a role in cell proliferation and programmed cell death.

How does RPS6KA1 influence neuronal development and function, especially in learning and memory processes?

RPS6KA1 is involved in neuronal development and function, affecting processes like learning and memory.

How do genetic mutations in RPS6KA1 contribute to the development of certain cancers and other diseases?

Genetic mutations in RPS6KA1 are linked to certain cancers and diseases, affecting its kinase activity and signaling functions.

How does RPS6KA1 interact with other kinases and signaling molecules in cellular signaling networks?

RPS6KA1 interacts with various kinases and signaling molecules, integrating multiple cellular signaling pathways.

What role does RPS6KA1 play in cellular responses to stress, particularly in cancer cells?

RPS6KA1 plays a crucial role in stress responses in cancer cells, influencing cell survival and adaptation mechanisms.

How does RPS6KA1 regulate protein synthesis and cell growth through the mTOR signaling pathway?

RPS6KA1 regulates protein synthesis and cell growth by modulating the mTOR pathway, affecting ribosomal protein activity.