Recombinant Human RRM2, GST-tagged

• Cat.No.: RRM2-2445H
• Product Overview: Recombinant Human RRM2 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 1-389aa
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: RRM2 ribonucleotide reductase M2 [ Homo sapiens ]
• Official Symbol: RRM2
• Synonyms: RRM2; ribonucleotide reductase M2; ribonucleotide reductase M2 polypeptide; ribonucleoside-diphosphate reductase subunit M2; ribonucleotide reductase small chain; ribonucleotide reductase small subunit; R2; RR2; RR2M
• Gene ID: 6241
• mRNA Refseq: NM_001034
• Protein Refseq: NP_001025
• MIM: 180390
• UniProt ID: P31350
• Chromosome Location: 2p25-p24
• Pathway: Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; E2F mediated regulation of DNA replication, organism-specific biosystem; E2F transcription factor network, organism-specific biosystem; Fluoropyrimidine Activity, organism-specific biosystem; G1/S Transition, organism-specific biosystem; G1/S-Specific Transcription, organism-specific biosystem
• Function: oxidoreductase activity; ribonucleoside-diphosphate reductase activity; ribonucleoside-diphosphate reductase activity; transition metal ion binding

Reviews

05/14/2022

The professional gave me a detailed description of the RRM2 protein so that I could understand its biochemical properties.

03/31/2021

Smooth communication and timely shipment, allowing my experiment to be implemented as soon as possible.

11/20/2020

Cheap price, high quality products, worth buying again!

Q&As

What diseases has RRM2 been associated with the study of?

RRM2 has been associated with studies of liver, lung, and breast cancers.

How is RRM2 related to tumor development?

Elevated expression of RRM2 in some malignant tumors promotes tumor cell proliferation and immune escape, leading to malignant tumor progression.

What is the function of RRM2?

RRM2, which catalyzes the formation of deoxyribonucleotides from ribonucleotides, is involved in processes such as DNA repair and the cell cycle.

What is the relationship between RRM2 and ANXA1?

RRM2 interacts with ANXA1.

What is the relationship between RRM2 and RRM2B?

Both RRM2 and RRM2B are two small subunits of RR.