Recombinant Human RRM2 Protein

• Cat.No.: RRM2-69H
• Product Overview: Recombinant Human RRM2 Protein was expressed in E. coli.

Specification

• Description: This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X.
• Source: E. coli
• Species: Human
• Form: Liquid. In 20 mM Tris-HCl, 100 mM NaCl, pH 8.0, containing 10% glycerol.
• Molecular Mass: ~47.0 kDa
• AA Sequence: MGSSHHHHHHSSGLVPRGSHMLSLR VPLAPITDPQQLQLSPLKGLSLVDK ENTPPALSGTRVLASKTARRIFQEP TEPKTKAAAPGVEDEPLLRENPRRF VIFPIEYHDIWQMYQKAEASFWTAE EVDLSKDIQHWESLKPEERYFISHV LAFFAASDGIVNENLVERFSQEVQI TEARCFYGFQIAMENIHSEMYSLLI DTYIKDPKEREFLFNAIETMPCVKK KADWALRWIGDKEATYGERVVAFAA VEGIFFSGSFASIFWLKKRGLMPGL TFSNELISRDEGLHCDFACLMFKHL VHKPSEERVREIIINAVRIEQEFLT EALPVKLIGMNCTLMKQYIEFVADR LMLELGFSKVFRVENPFDFMENISL EGKTNFFEKRVGEYQRMGVMSSPTE NSFTLDADF
• Purity: >90%
• Storage: Short Term Storage at 4 centigrade, Long Term, please prepare aliquots with 20% glycerol and store at -20 to -80 centigrade. Avoid freeze/thaw cycles.
• Concentration: 0.1 mg/ml
• Official Full Name: Ribonucleotide reductase regulatory subunit M2

Gene Information

• Gene Name: RRM2 ribonucleotide reductase regulatory subunit M2 [ Homo sapiens (human) ]
• Official Symbol: RRM2
• Synonyms: R2; RR2; RR2M; C2orf48
• Gene ID: 6241
• mRNA Refseq: NM_001034
• Protein Refseq: NP_001025
• MIM: 180390
• UniProt ID: P31350

Reviews

05/14/2022

The professional gave me a detailed description of the RRM2 protein so that I could understand its biochemical properties.

03/31/2021

Smooth communication and timely shipment, allowing my experiment to be implemented as soon as possible.

11/20/2020

Cheap price, high quality products, worth buying again!

Q&As

What diseases has RRM2 been associated with the study of?

RRM2 has been associated with studies of liver, lung, and breast cancers.

How is RRM2 related to tumor development?

Elevated expression of RRM2 in some malignant tumors promotes tumor cell proliferation and immune escape, leading to malignant tumor progression.

What is the function of RRM2?

RRM2, which catalyzes the formation of deoxyribonucleotides from ribonucleotides, is involved in processes such as DNA repair and the cell cycle.

What is the relationship between RRM2 and ANXA1?

RRM2 interacts with ANXA1.

What is the relationship between RRM2 and RRM2B?

Both RRM2 and RRM2B are two small subunits of RR.