Recombinant Human RYBP Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | RYBP-2901H |
Product Overview : | RYBP MS Standard C13 and N15-labeled recombinant protein (NP_036366) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
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Description : | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites. Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis. May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. May bind to DNA. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 24.9 kDa |
AA Sequence : | MTMGDKKSPTRPKRQAKPATDEGFW DCSVCTFRNSAEAFKCSICDVRKGT STRKPRINSQLVAQQVAQQYATPPP PKKEKKEKVEKQDKEKPEKDKEISP SVTKKNTNKKTKPKSDILKDPPSEA NSIQSANATTKTSETNHTSRPRLKN VDRSTAQQLAVTVGNVTVIITDFKE KTRSSSTSSSTVTSSAGSEQQNQSS SGSESTDKGSSRSSTPKGDMSAVND ESFTRTRPLEQKLISEEDLAANDIL DYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | RYBP RING1 and YY1 binding protein [ Homo sapiens (human) ] |
Official Symbol : | RYBP |
Synonyms : | RYBP; RING1 and YY1 binding protein; RING1 and YY1-binding protein; AAP1; apoptin associating protein 1; death effector domain associated factor; DEDAF; ring1 interactor RYBP; YEAF1; YY1 and E4TF1 associated factor 1; APAP-1; DED-associated factor; apoptin-associating protein 1; YY1 and E4TF1-associated factor 1; death effector domain-associated factor; |
Gene ID : | 23429 |
mRNA Refseq : | NM_012234 |
Protein Refseq : | NP_036366 |
MIM : | 607535 |
UniProt ID : | Q8N488 |
Products Types
◆ Recombinant Protein | ||
RYBP-3236H | Recombinant Human RYBP protein(Met1-Phe228), His&GST-tagged | +Inquiry |
RYBP-7861M | Recombinant Mouse RYBP Protein, His (Fc)-Avi-tagged | +Inquiry |
RYBP-2011H | Recombinant Human RYBP Protein, MYC/DDK-tagged | +Inquiry |
Rybp-5662M | Recombinant Mouse Rybp Protein, Myc/DDK-tagged | +Inquiry |
RYBP-6846H | Recombinant Human RING1 And YY1 Binding Protein, His-tagged | +Inquiry |
◆ Lysates | ||
RYBP-001HCL | Recombinant Human RYBP cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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