Recombinant Human S100A11 protein, His-tagged

• Cat.No.: S100A11-3441H
• Product Overview: Recombinant Human S100A11(1-105aa) fused with His tag at N-terminal was expressed in E. coli.

Specification

• Description: S100A11 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. This protein may function in motility, invasion, and tubulin polymerization.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 30% glycerol, 0.1M NaCl, 1mM DTT
• Molecular Mass: 14.2kDa (128aa) confirmed by MALDI-TOF
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSHLDTNSDGQLD FSEFLNLIGG LAMACHDSFL KAVPSQKRT MAKISS PTETERCIES LIAVFQKYAG KDGYNYTLSK TEFLSFMNTE LAAFTKNQKD PGVLDRMMKK
• Purity: >95% by SDS - PAGE
• Storage: Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
• Concentration: 1.0 mg/ml (determined by BCA assay)

Gene Information

• Gene Name: S100A11 S100 calcium binding protein A11 [ Homo sapiens ]
• Official Symbol: S100A11
• Synonyms: S100A11; S100 calcium binding protein A11; S100 calcium binding protein A11 (calgizzarin) , S100 calcium binding protein A11 (calgizzarin); protein S100-A11; S100C; MLN 70; calgizzarin; protein S100-C; metastatic lymph node gene 70 protein; S100 calcium-binding protein A11 (calgizzarin); MLN70
• Gene ID: 6282
• mRNA Refseq: NM_005620
• Protein Refseq: NP_005611
• MIM: 603114
• UniProt ID: P31949
• Chromosome Location: 1q21
• Function: S100 beta binding; calcium ion binding; calcium-dependent protein binding; protein binding; protein homodimerization activity

Reviews

03/09/2021

Quality product, delivered on time—perfect!

01/30/2019

Fantastic quality, hassle-free delivery!

10/16/2018

A+ for both product quality and excellent service!

Q&As

Can you elaborate on the role of S100A11 in cellular signaling pathways, particularly those involved in cancer progression and metastasis?

S100A11 participates in multiple signaling pathways, influencing cancer progression and metastasis. It interacts with proteins involved in cell motility, invasion, and angiogenesis, contributing to the malignant phenotype.

How does S100A11 contribute to cellular differentiation, and are there specific target genes or pathways involved in this process?

S100A11 plays a role in cellular differentiation, influencing specific target genes and pathways. Its involvement in differentiation programs is context-dependent and varies across cell types.

How is S100A11 expression regulated, and what are the transcriptional and post-translational mechanisms influencing its activity?

S100A11 expression is regulated at transcriptional and post-translational levels. Transcription factors and signaling pathways control its mRNA levels, while post-translational modifications such as phosphorylation modulate its activity.

In neurodegenerative diseases, is there evidence of S100A11 involvement, and what are the potential mechanisms linking this protein to neurological pathology?

Emerging evidence suggests a potential role for S100A11 in neurodegenerative diseases. The mechanisms linking S100A11 to neurological pathology involve its interactions with proteins and signaling cascades.

What is S100A11, and what is its cellular localization and physiological role?

S100A11 is a member of the S100 protein family, predominantly located in the cytoplasm and nucleus. Its physiological roles include regulation of cell proliferation, differentiation, and apoptosis.