Recombinant Human S100A11 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: S100A11-3444H
• Product Overview: S100A11 MS Standard C13 and N15-labeled recombinant protein (NP_005611) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 11.7 kDa
• AA Sequence: MAKISSPTETERCIESLIAVFQKYA GKDGYNYTLSKTEFLSFMNTELAAF TKNQKDPGVLDRMMKKLDTNSDGQL DFSEFLNLIGGLAMACHDSFLKAVP SQKRTTRTRPLEQKLISEEDLAAND ILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: S100A11 S100 calcium binding protein A11 [ Homo sapiens (human) ]
• Official Symbol: S100A11
• Synonyms: S100A11; S100 calcium binding protein A11; S100 calcium binding protein A11 (calgizzarin), S100 calcium binding protein A11 (calgizzarin); protein S100-A11; S100C; MLN 70; calgizzarin; protein S100-C; metastatic lymph node gene 70 protein; S100 calcium-binding protein A11 (calgizzarin); MLN70
• Gene ID: 6282
• mRNA Refseq: NM_005620
• Protein Refseq: NP_005611
• MIM: 603114
• UniProt ID: P31949

Reviews

03/09/2021

Quality product, delivered on time—perfect!

01/30/2019

Fantastic quality, hassle-free delivery!

10/16/2018

A+ for both product quality and excellent service!

Q&As

Can you elaborate on the role of S100A11 in cellular signaling pathways, particularly those involved in cancer progression and metastasis?

S100A11 participates in multiple signaling pathways, influencing cancer progression and metastasis. It interacts with proteins involved in cell motility, invasion, and angiogenesis, contributing to the malignant phenotype.

How does S100A11 contribute to cellular differentiation, and are there specific target genes or pathways involved in this process?

S100A11 plays a role in cellular differentiation, influencing specific target genes and pathways. Its involvement in differentiation programs is context-dependent and varies across cell types.

How is S100A11 expression regulated, and what are the transcriptional and post-translational mechanisms influencing its activity?

S100A11 expression is regulated at transcriptional and post-translational levels. Transcription factors and signaling pathways control its mRNA levels, while post-translational modifications such as phosphorylation modulate its activity.

In neurodegenerative diseases, is there evidence of S100A11 involvement, and what are the potential mechanisms linking this protein to neurological pathology?

Emerging evidence suggests a potential role for S100A11 in neurodegenerative diseases. The mechanisms linking S100A11 to neurological pathology involve its interactions with proteins and signaling cascades.

What is S100A11, and what is its cellular localization and physiological role?

S100A11 is a member of the S100 protein family, predominantly located in the cytoplasm and nucleus. Its physiological roles include regulation of cell proliferation, differentiation, and apoptosis.