| Description : |
May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates, phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be involved in the plasma membrane localization of CTNNB1. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
79.3 kDa |
| AA Sequence : |
MEASVILPILKKKLAFLSGGKDRRS GLILTIPLCLEQTNMDELSVTLDFL LSIPSEKCKARGFTVIVDGRKSQWN VVKTVVVMLQNVVPAEVSLVCVVKP DEFWDKKVTHFCFWKEKDRLGFEVI LVSANKLTRYIEPCQLTEDFGGSLT YDHMDWLNKRLVFEKFTKESTSLLD ELALINNGSDKGNQQEKERSVDLNF LPSVDPETVLQTGHELLSELQQRRF NGSDGGVSWSPMDDELLAQPQVMKL LDSLREQYTRYQEVCRQRSKRTQLE EIQQKVMQVVNWLEGPGSEQLRAQW GIGDSIRASQALQQKHEEIESQHSE WFAVYVELNQQIAALLNAGDEEDLV ELKSLQQQLSDVCYRQASQLEFRQN LLQAALEFHGVAQDLSQQLDGLLGM LCVDVAPADGASIQQTLKLLEEKLK SVDVGLQGLREKGQGLLDQISNQAS WAYGKDVTIENKENVDHIQGVMEDM QLRKQRCEDMVDVRRLKMLQMVQLF KCEEDAAQAVEWLSELLDALLKTHI RLGDDAQETKVLLEKHRKFVDVAQS TYDYGRQLLQATVVLCQSLRCTSRS SGDTLPRLNRVWKQFTIASEERVHR LEMAIAFHSNAEKILQDCPEEPEAI NDEEQFDEIEAVGKSLLDRLTVPVV YPDGTEQYFGSPSDMASTAENIRDR MKLVNLKRQQLRHPEMVTTESTRTR PLEQKLISEEDLAANDILDYKDDDD KV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
