Recombinant Human SF3A3, His-tagged

• Cat.No.: SF3A3-30078TH
• Product Overview: Recombinant fragment, corresponding to amino acids 97-501 of Human SF3A3 with N terminal His tag; 405 amino acids, 54kDa.

Specification

• Description: This gene encodes subunit 3 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 3 interacts with subunit 1 through its amino-terminus while the zinc finger domain of subunit 3 plays a role in its binding to the 15S U2 snRNP. This gene has a pseudogene on chromosome 20.
• Conjugation: HIS
• Source: E. coli
• Form: Lyophilised:Reconstitute with 149 μl aqua dest.
• Storage buffer: Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: KHPNEICVPMSVEFEELLKARENPSEEAQNLVEFTDEEGY GRYLDLHDCYLKYINLKASEKLDYITYLSIFDQLFDIP KERKNAEYKRYLEMLLEYLQDYTDRVKPLQDQNELFGKIQ AEFEKKWENGTFPGWPKETSSALTHAGAHLDLSAFSSW EELASLGLDRLKSALLALGLKCGGTLEERAQRLFSTKG KSLESLDTSLFAKNPKSKGTKRDTERNKDIAFLEAQIYEY VEILGEQRHLTHENVQRKQARTGEEREEEEEEQISESE SEDEENEIIYNPKNLPLGWDGKPIPYWLYKLHGLNINYNC EICGNYTYRGPKAFQRHFAEWRHAHGMRCLGIPNTAHF ANVTQIEDAVSLWAKLKLQKASERWQPDTEEEYEDSSG NVVNKKTYEDLKRQGLL

Gene Information

• Gene Name: SF3A3 splicing factor 3a, subunit 3, 60kDa [ Homo sapiens ]
• Official Symbol: SF3A3
• Synonyms: SF3A3; splicing factor 3a, subunit 3, 60kDa; splicing factor 3a, subunit 3, 60kD; splicing factor 3A subunit 3; PRP9; PRPF9; SAP61; SF3a60
• Gene ID: 10946
• mRNA Refseq: NM_006802
• Protein Refseq: NP_006793
• MIM: 605596
• Uniprot ID: Q12874
• Chromosome Location: 1p
• Pathway: Diurnally regulated genes with circadian orthologs, organism-specific biosystem; Formation and Maturation of mRNA Transcript, organism-specific biosystem; Gene Expression, organism-specific biosystem; Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem; Spliceosome, organism-specific biosystem
• Function: metal ion binding; nucleic acid binding; zinc ion binding