Recombinant Human SH2 Domain Containing 1A, His-tagged
Cat.No. : | SH2D1A-4591H |
Product Overview : | SH2D1A Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 148 amino acids (1-128 a.a.) and having a molecular mass of 16.3kDa. The SH2D1A is purified by proprietary chromatographic techniques. |
- Specification
- Gene Information
- Related Products
Cat. No. : | SH2D1A-4591H |
Description : | SH2D1A acts as an inhibitor of the signaling lymphocyte activation molecule (SLAM) self-association. The SH2D1A protein is expressed at a high level in the thymus and the lung, with a lower level of expression in the spleen and the liver. The SH2D1A protein contains an SH2 domain and a short tail. SH2D1A has a key role in the bidirectional stimulation of T and B cells. Defects in the SH2D1A gene cause the X-linked lymphoproliferative disease (XLPD), aka Duncan disease. The XLPD is distinguished by a rare congenital immunodeficiency following an EBV infection (Epstein-Barr virus). |
Source : | Human |
Host : | Escherichia Coli. |
Form : | The SH2D1A solution (1 mg/ml) contains 20mM Tris-HCl Buffer (pH 7.5), 1mM DTT and 10% Glycerol. |
Purity : | Greater than 95.0% as determined by SDS-PAGE. |
Physical Appearance : | Sterile Filtered colorless solution. |
Amino acid sequence : | MGSSHHHHHH SSGLVPRGSH MDAVAVYHGK ISRETGEKLL LATGLDGSYL LRDSESVPGV YCLCVLYHGY IYTYRVSQTE TGSWSAETAP GVHKRYFRKI KNLISAFQKP DQGIVIPLQY PVEKKSSARS TQGTTGIRED PDVCLKAP. |
Storage : | SH2D1A should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
Gene Name : | SH2D1A SH2 domain containing 1A [ Homo sapiens ] |
Official Symbol : | SH2D1A |
Synonyms : | SH2D1A; LYP; SAP; XLP; DSHP; EBVS; IMD5; XLPD; MTCP1; FLJ18687; FLJ92177; SAP/SH2D1A; SH2 domain-containing protein 1A; OTTHUMP00000023976; OTTHUMP00000226563; SLAM-associated protein; Duncan disease SH2-protein; T cell signal transduction molecule SAP; SLAM associated protein/SH2 domain protein 1A; signaling lymphocyte activation molecule-associated protein; signaling lymphocytic activation molecule-associated protein |
Gene ID : | 4068 |
mRNA Refseq : | NM_001114937 |
Protein Refseq : | NP_001108409 |
MIM : | 300490 |
UniProt ID : | O60880 |
Chromosome Location : | Xq25 |
Pathway : | Direct p53 effectors; Measles; Natural killer cell mediated cytotoxicity |
Function : | SH3/SH2 adaptor activity |
Products Types
◆ Recombinant Protein | ||
SH2D1A-22H | Recombinant Human SH2D1A Protein, MYC/DDK-tagged | +Inquiry |
SH2D1A-4001R | Recombinant Rhesus Macaque SH2D1A Protein, His (Fc)-Avi-tagged | +Inquiry |
Sh2d1a-5834M | Recombinant Mouse Sh2d1a Protein, Myc/DDK-tagged | +Inquiry |
SH2D1A-5033R | Recombinant Rat SH2D1A Protein, His (Fc)-Avi-tagged | +Inquiry |
SH2D1A-8116M | Recombinant Mouse SH2D1A Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
SH2D1A-1879HCL | Recombinant Human SH2D1A 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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