Description : |
The protein encoded by this gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases, and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene. |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Myc/DDK |
Molecular Mass : |
62.2 kDa |
AA Sequence : |
MAAEEMHWPVPMKAIGAQNLLTMPG GVAKAGYLHKKGGTQLQLLKWPLRF VIIHKRCVYYFKSSTSASPQGAFSL SGYNRVMRAAEETTSNNVFPFKIIH ISKKHRTWFFSASSEEERKSWMALL RREIGHFHEKKDLPLDTSDSSSDTD SFYGAVERPVDISLSPYPTDNEDYE HDDEDDSYLEPDSPEPGRLEDALMH PPAYPPPPVPTPRKPAFSDMPRAHS FTSKGPGPLLPPPPPKHGLPDVGLA AEDSKRDPLCPRRAEPCPRVPATPR RMSDPPLSTMPTAPGLRKPPCFRES ASPSPEPWTPGHGACSTSSAAIMAT ATSRNCDKLKSFHLSPRGPPTSEPP PVPANKPKFLKIAEEDPPREAAMPG LFVPPVAPRPPALKLPVPEAMARPA VLPRPEKPQLPHLQRSPPDGQSFRS FSFEKPRQPSQADTGGDDSDEDYEK VPLPNSVFVNTTESCEVERLFKATS PRGEPQDGLYCIRNSSTKSGKVLVV WDETSNKVRNYRIFEKDSKFYLEGE VLFVSVGSMVEHYHTHVLPSHQSLL LRHPYGYTGPRTRTRPLEQKLISEE DLAANDILDYKDDDDKV |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : |
50 μg/mL as determined by BCA |
Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |