Recombinant Human SHARPIN Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | SHARPIN-1033H |
Product Overview : | SHARPIN MS Standard C13 and N15-labeled recombinant protein (NP_112236) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
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Description : | Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 39.8 kDa |
AA Sequence : | MAPPAGGAAAAASDLGSAAVLLAVH AAVRPLGAGPDAEAQLRRLQLSADP ERPGRFRLELLGAGPGAVNLEWPLE SVSYTIRGPTQHELQPPPGGPGTLS LHFLNPQEAQRWAVLVRGATVEGQN GSKSNSPPALGPEACPVSLPSPPEA STLKGPPPEADLPRSPGNLTEREEL AGSLARAIAGGDEKGAAQVAAVLAQ HRVALSVQLQEACFPPGPIRLQVTL EDAASAASAASSAHVALQVHPHCTV AALQEQVFSELGFPPAVQRWVIGRC LCVPERSLASYGVRQDGDPAFLYLL SAPREAPATGPSPQHPQKMDGELGR LFPPSLGLPPGPQPAASSLPSPLQP SWSCPSCTFINAPDRPGCEMCSTQR PCTWDPLAAASTTRTRPLEQKLISE EDLAANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | SHARPIN SHANK-associated RH domain interactor [ Homo sapiens (human) ] |
Official Symbol : | SHARPIN |
Synonyms : | SHARPIN; SHANK-associated RH domain interactor; sharpin; DKFZP434N1923; SIPL1; hSIPL1; shank-interacting protein-like 1; shank-associated RH domain-interacting protein; DKFZp434N1923; |
Gene ID : | 81858 |
mRNA Refseq : | NM_030974 |
Protein Refseq : | NP_112236 |
MIM : | 611885 |
UniProt ID : | Q9H0F6 |
Products Types
◆ Recombinant Protein | ||
SHARPIN-8138M | Recombinant Mouse SHARPIN Protein, His (Fc)-Avi-tagged | +Inquiry |
Sharpin-288M | Recombinant Mouse Sharpin Protein, MYC/DDK-tagged | +Inquiry |
SHARPIN-5047R | Recombinant Rat SHARPIN Protein, His (Fc)-Avi-tagged | +Inquiry |
SHARPIN-2653H | Recombinant Human SHARPIN, GST-tagged | +Inquiry |
SHARPIN-3420H | Recombinant Human SHARPIN protein, His-tagged | +Inquiry |
◆ Lysates | ||
SHARPIN-1601HCL | Recombinant Human SHARPIN cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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