| Description : |
Two families of mammalian lectin-like adhesion molecules, the selectins and the sialoadhesins, bind glycoconjugate ligands in a sialic acid-dependent manner. The sialic acid-binding immunoglobulin superfamily lectins, designated Siglecs or sialoadhesins, recognize sialylated ligands and play a key role in mediating sialic-acid dependent binding to cells. Siglec-6, also called obesitybinding protein 1, is an adhesion molecule that is highly expressed in placental trophoblasts, as well as in peripheral blood leukocytes. Siglec-6 can bind both N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc), the two common sialic acids found in mammalian cells. Together with the other members of the Siglec family, Siglec-6 promotes cell-cell interactions and plays a roll in the innate and adaptive immune systems through glycan recognition. |
| Source : |
E. coli |
| Species : |
Human |
| Tag : |
His |
| Molecular Mass : |
~35 kDa |
| AA Sequence : |
QERRFQLEGPESLTVQEGLCVLVPC RLPTTLPASYYGYGYWFLEGADVPV ATNDPDEEVQEETRGRFHLLWDPRR KNCSLSIRDARRRDNAAYFFRLKSK WMKYGYTSSKLSVRVMALTHRPNIS IPGTLESGHPSNLTCSVPWVCEQGT PPIFSWMSAAPTSLGPRTTQSSVLT ITPRPQDHSTNLTCQVTFPGAGVTM ERTIQLNVSYAPQKVAISIFQGNSA AFKILQNTSSLPVLEGQALRLLCDA DGNPPAHLSWFQGFPALNATPISNT GVLELPQVGSAEEGDFTCRAQHPLG SLQISLSLFVHWKPEGRAGGV |
| Purity : |
Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE). |
| Notes : |
For research use only, not for use in diagnostic procedure. |
| Storage : |
Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles. |
| Concentration : |
≥0.5 mg/mL |
| Storage Buffer : |
PBS, 4M Urea, pH7.4 |
