Recombinant Human SIRT4 Protein (Ser28-Cys314), His tagged

• Cat.No.: SIRT4-3477H
• Product Overview: Recombinant human SIRT4 (Ser28-Cys314) protein fused with His tag was expressed in E. coli.

Specification

• Description: Downregulation of SIRT4 significantly increased tumor proliferation, migration and invasion. Additionally, downregulation of SIRT4 decreased the chemosensitivity of CRC cells by inhibiting cell apoptosis. Thus, these results suggest that SIRT4 may be a promising therapeutic target in CRC. SIRT4 in the control of energy metabolism and meiotic apparatus during oocyte maturation and indicate that SIRT4 is an essential factor determining oocyte quality. SIRT4 ameliorates MI-R injury through regulating mitochondrial function and apoptosis, and suggest that manipulating SIRT4 may be of clinical benefit in MI-R injury.
• Source: E. coli
• Species: Human
• Tag: His
• Molecular Mass: 33.05 kDa
• Protein Length: Ser28-Cys314
• Purity: >90 % as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: SIRT4 sirtuin 4 [ Homo sapiens (human) ]
• Official Symbol: SIRT4
• Synonyms: SIRT4; sirtuin 4; sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae), sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 4; NAD-dependent ADP-ribosyltransferase sirtuin-4; SIR2L4; sir2-like 4; sirtuin type 4; SIR2-like protein 4; MGC57437; MGC130046; MGC130047
• Gene ID: 23409
• mRNA Refseq: NM_012240
• Protein Refseq: NP_036372
• MIM: 604482
• UniProt ID: Q9Y6E7