Recombinant Human SNCB, His-tagged
Cat.No. : | SNCB-246H |
Product Overview : | Recombinant full length human SNCB was expressed in E. coli cells using an N-terminal His tag. |
- Specification
- Gene Information
- Related Products
Description : | SNCB is a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. SNCB is highly homologous to alpha-synuclein which is abundantly expressed in the brain and putatively inhibits phospholipase D2 selectively. SNCB may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. SNCB is shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease but no direct relation to Parkinson disease has been established. An alteration in SNCB may impair its normal inhibitory action on the formation of toxic alpha-synuclein fibrils, thereby indirectly contributing to disease pathogenesis. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Recombinant protein stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol. |
Molecular Mass : | ~19 kDa |
Purity : | >95% by densitometry |
Applications : | Western Blot |
Storage : | Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.2 μg/μl |
Gene Name : | SNCB synuclein, beta [ Homo sapiens ] |
Official Symbol : | SNCB |
Synonyms : | SNCB; synuclein, beta; beta-synuclein; |
Gene ID : | 6620 |
mRNA Refseq : | NM_001001502 |
Protein Refseq : | NP_001001502 |
MIM : | 602569 |
UniProt ID : | Q16143 |
Chromosome Location : | 5q35 |
Function : | calcium ion binding; phospholipase inhibitor activity; |
Products Types
◆ Recombinant Protein | ||
Sncb-249M | Recombinant Mouse Sncb Protein, MYC/DDK-tagged | +Inquiry |
SNCB-2457M | Recombinant Mouse SNCB Protein (1-133 aa) | +Inquiry |
SNCB-5298R | Recombinant Rat SNCB Protein, His (Fc)-Avi-tagged | +Inquiry |
SNCB-4182R | Recombinant Rhesus Macaque SNCB Protein, His (Fc)-Avi-tagged | +Inquiry |
SNCB-245H | Recombinant Human SNCB Protein, MYC/DDK-tagged | +Inquiry |
◆ Native Protein | ||
SNCB-27206TH | Native Human SNCB | +Inquiry |
◆ Lysates | ||
SNCB-1632HCL | Recombinant Human SNCB 293 Cell Lysate | +Inquiry |
SNCB-1631HCL | Recombinant Human SNCB 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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