Recombinant Human SOD1 protein, His-tagged
Cat.No. : | SOD1-642H |
Product Overview : | Recombinant Human SOD1 protein, fused to His-tag at N-terminus, was expressed in Escherichia coli. |
- Specification
- Gene Information
- Related Products
- Download
Description : | Superoxide dismutase catalyzes the reaction between superoxide anions and hydrogen to yield molecular oxygen and hydrogen peroxide. Cu/Zn superoxide dismutase also named as SOD1, is an enzyme encoded by the SOD1 gene in humans, located on chromosome 21. The SOD1 binds Cu and Zn ions and is one of three SODs responsible for destroying free superoxide radicals in the body. It has been shown to interact with CCS and Bcl-2. The malfunction of SOD1 may increase the risk of illnesses like age-related muscle mass loss (sarcopenia), early development of cataracts, macular degeneration, thymic involution, hepatocellular carcinoma, shortened lifespan, keratoconus and amyotrophic lateral sclerosis. |
Source : | E.coli |
Species : | Human |
Tag : | His |
Form : | Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH 7.4. |
Bio-activity : | Fully biologically active when compared to standard. The potency per mg was determined by Pyrogallic Acid method and was found to be more than 1.0 × 10⁴ IU/mg. |
Molecular Mass : | Approximately 39.9 kDa, a homodimer, non-glycosylated polypeptide chain containing 2 × 189 amino acids with Met, Gly and 10 × His at N-terminus. |
Protein length : | 189 |
AA Sequence : | MGHHHHHHHHHHSSGHIEGRHMTYA RAAARQARALEATKAVCVLKGDGPV QGIINFEQKESNGPVKVWGSIKGLT EGLHGFHVHEFGDNTAGCTSAGPHF NPLSRKHGGPKDEERHVGDLGNVTA DKDGVADVSIEDSVISLSGDHCIIG RTLVVHEKADDLGKGGNEESTKTGN AGSRLACGVIGIAQ |
Endotoxin : | Less than 1 EU/μg of rHuCu/Zn SOD, His as determined by LAL method. |
Purity : | >95% by SDS-PAGE and HPLC analysis. |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution. |
Reconstitution : | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤-20 centigrade. Further dilutions should be made in appropriate buffered solutions. |
Gene Name : | SOD1 |
Official Symbol : | SOD1 |
Synonyms : | SOD1; superoxide dismutase 1, soluble; ALS, ALS1, amyotrophic lateral sclerosis 1 (adult); superoxide dismutase [Cu-Zn]; IPOA; SOD, soluble; indophenoloxidase A; Cu/Zn superoxide dismutase; superoxide dismutase, cystolic; ALS; SOD; ALS1; hSod1; homodimer; |
Gene ID : | 6647 |
mRNA Refseq : | NM_000454 |
Protein Refseq : | NP_000445 |
MIM : | 147450 |
UniProt ID : | P00441 |
Products Types
◆ Native Protein | ||
SOD1-102B | Active Native Bovine SOD, modified | +Inquiry |
CED026 | Active Bovine Superoxide Dismutase (SOD), High Purity >95% | +Inquiry |
SOD1-101B | Active Native Bovine SOD | +Inquiry |
◆ Lysates | ||
SOD1-1576HCL | Recombinant Human SOD1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (7)
Ask a questionTherapeutic strategies may involve modulating SOD1 activity or expression to mitigate oxidative stress-related damage.
SOD1 acts as an antioxidant, converting superoxide radicals to hydrogen peroxide and oxygen.
Mutations in SOD1 can result in loss or gain of function, contributing to disease development.
SOD1 mutations are implicated in Amyotrophic Lateral Sclerosis (ALS), leading to neurodegeneration.
SOD1 is primarily located in the cytoplasm and mitochondrial intermembrane space.
It helps maintain cellular redox balance, protecting cells from oxidative damage.
It plays a crucial role in cellular defense against oxidative stress.
Customer Reviews (3)
Write a reviewWorked perfectly, no problems.
Quick delivery, fantastic product.
Reliable results every time.
Ask a Question for All SOD1 Products
Required fields are marked with *
My Review for All SOD1 Products
Required fields are marked with *
Inquiry Basket