Recombinant Human SOD1 Protein (Met1-Gln154), N-His tagged

• Cat.No.: SOD1-6332H
• Product Overview: Recombinant human SOD1 (Met1-Gln154) fused with the N-terminal His tag was expressed in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: N-His
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 16.94 kDa
• Protein Length: Met1-Gln154
• Purity: > 90 % as determined by SDS-PAGE
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS or lyophilized from PBS.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: SOD1 superoxide dismutase 1, soluble [ Homo sapiens (human) ]
• Official Symbol: SOD1
• Synonyms: SOD1; superoxide dismutase 1, soluble; ALS, ALS1, amyotrophic lateral sclerosis 1 (adult); superoxide dismutase [Cu-Zn]; IPOA; SOD, soluble; indophenoloxidase A; Cu/Zn superoxide dismutase; superoxide dismutase, cystolic; ALS; SOD; ALS1; hSod1; homodimer
• Gene ID: 6647
• mRNA Refseq: NM_000454
• Protein Refseq: NP_000445
• MIM: 147450
• UniProt ID: P00441

Reviews

11/15/2022

Worked perfectly, no problems.

10/09/2020

Quick delivery, fantastic product.

10/02/2020

Reliable results every time.

Q&As

Are there potential therapeutic strategies targeting SOD1 for disease treatment?

Therapeutic strategies may involve modulating SOD1 activity or expression to mitigate oxidative stress-related damage.

What is the primary biological function of SOD1 in cells?

SOD1 acts as an antioxidant, converting superoxide radicals to hydrogen peroxide and oxygen.

What are the genetic implications of mutations in the SOD1 gene?

Mutations in SOD1 can result in loss or gain of function, contributing to disease development.

How is SOD1 implicated in neurodegenerative diseases?

SOD1 mutations are implicated in Amyotrophic Lateral Sclerosis (ALS), leading to neurodegeneration.

In which cellular compartments is SOD1 primarily located?

SOD1 is primarily located in the cytoplasm and mitochondrial intermembrane space.

What role does SOD1 play in maintaining cellular redox balance?

It helps maintain cellular redox balance, protecting cells from oxidative damage.

How does SOD1 contribute to the cellular antioxidant defense system?

It plays a crucial role in cellular defense against oxidative stress.