Recombinant Human SORD Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: SORD-5389H
• Product Overview: SORD MS Standard C13 and N15-labeled recombinant protein (NP_003095) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications. The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 38.3 kDa
• AA Sequence: MAAAAKPNNLSLVVHGPGDLRLENY PIPEPGPNEVLLRMHSVGICGSDVH YWEYGRIGNFIVKKPMVLGHEASGT VEKVGSSVKHLKPGDRVAIEPGAPR ENDEFCKMGRYNLSPSIFFCATPPD DGNLCRFYKHNAAFCYKLPDNVTFE EGALIEPLSVGIHACRRGGVTLGHK VLVCGAGPIGMVTLLVAKAMGAAQV VVTDLSATRLSKAKEIGADLVLQIS KESPQEIARKVEGQLGCKPEVTIEC TGAEASIQAGIYATRSGGTLVLVGL GSEMTTVPLLHAAIREVDIKGVFRY CNTWPVAISMLASKSVNVKPLVTHR FPLEKALEAFETFKKGLGLKIMLKC DPSDQNPTRTRPLEQKLISEEDLAA NDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: SORD sorbitol dehydrogenase [ Homo sapiens (human) ]
• Official Symbol: SORD
• Synonyms: SORD; sorbitol dehydrogenase; L-iditol 2-dehydrogenase; SORD1
• Gene ID: 6652
• mRNA Refseq: NM_003104
• Protein Refseq: NP_003095
• MIM: 182500
• UniProt ID: Q00796