Description : |
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. |
Source : |
HEK293 |
Species : |
Human |
Tag : |
His |
Form : |
Lyophilized |
Molecular Mass : |
22.5 kDa |
Protein Length : |
213 |
AA Sequence : |
MQLPLALCLVCLLVHTAFRVVEGQG WQAFKNDATEIIPELGEYPEPPPEL ENNKTMNRAENGGRPPHHPFETKDV SEYSCRELHFTRYVTDGPCRSAKPV TELVCSGQCGPARLLPNAIGRGKWW RPSGPDFRCIPDRYRAQRVQLLCPG GEAPRARKVRLVASCKCKRLTRFHN QSELKDFGTEAARPQKGRKPRPRAR SAKANQAELENAY |
Purity : |
> 98% |
Applications : |
WB; ELISA; FACS; FC |
Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
Storage : |
At -20 centigrade. |
Concentration : |
1 mg/mL |
Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |