Recombinant Human SPHK1 Protein (Ser148-Leu398), His tagged
Cat.No. : | SPHK1-6675H |
Product Overview : | Recombinant human SPHK1 (Ser148-Leu398) fused with His tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D, L-threo-dihydrosphingosine, N, N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol. In contrast to proapoptotic SPHK2, has a negative effect on intracellular ceramide levels, enhances cell growth and inhibits apoptosis. Involved in the regulation of inflammatory response and neuroinflammation. Via the product sphingosine 1-phosphate, stimulates TRAF2 E3 ubiquitin ligase activity, and promotes activation of NF-kappa-B in response to TNF signaling leading to IL17 secretion. In response to TNF and in parallel to NF-kappa-B activation, negatively regulates RANTES induction through p38 MAPK signaling pathway. Involved in endocytic membrane trafficking induced by sphingosine, recruited to dilate endosomes, also plays a role on later stages of endosomal maturation and membrane fusion independently of its kinase activity. In Purkinje cells, seems to be also involved in the regulation of autophagosome-lysosome fusion upon VEGFA. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Lyophilized powder/frozen liquid |
Molecular Mass : | 28.51 kDa |
Protein Length : | Ser148-Leu398 |
Purity : | > 90 % as determined by SDS-PAGE |
Notes : | For research use only. |
Storage : | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt. |
Storage Buffer : | Supplied as solution form in PBS, pH 7.5 or lyophilized from PBS, pH 7.5. |
Reconstitution : | Reconstitute in sterile water for a stock solution. |
Shipping : | They are shipped out with dry ice/blue ice unless customers require otherwise. |
Gene Name : | SPHK1 sphingosine kinase 1 [ Homo sapiens (human) ] |
Official Symbol : | SPHK1 |
Synonyms : | SPHK1; sphingosine kinase 1; SPHK; SK 1; SPK 1; |
Gene ID : | 8877 |
mRNA Refseq : | NM_001142601 |
Protein Refseq : | NP_001136073 |
MIM : | 603730 |
UniProt ID : | Q9NYA1 |
Products Types
◆ Recombinant Protein | ||
SPHK1-0269H | Recombinant Human SPHK1 Protein (M1-S363), Tag Free | +Inquiry |
SPHK1-4130H | Recombinant Human SPHK1 Protein, His (Fc)-Avi-tagged | +Inquiry |
SPHK1-0268H | Recombinant Human SPHK1 Protein (M1-S363), His tagged | +Inquiry |
SPHK1-1331H | Acitve Recombinant Human SPHK1 protein(Met1-Leu384) | +Inquiry |
SPHK1-2567H | Recombinant Human SPHK1 Protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
SPHK1-001HCL | Recombinant Human SPHK1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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