| Description : |
This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
34.7 kDa |
| AA Sequence : |
MEARAQSGNGSQPLLQTPRDGGRQR GEPDPRDALTQQVHVLSLDQIRAIR NTNEYTEGPTVVPRPGLKPAPRPST QHKHERLHGLPEHRQPPRLQHSQVH SSARAPLSRSISTVSSGSRSSTRTS TSSSSSEQRLLGSSFSSGPVADGII RVQPKSELKPGELKPLSKEDLGLHA YRCEDCGKCKCKECTYPRPLPSDWI CDKQCLCSAQNVIDYGTCVCCVKGL FYHCSNDDEDNCADNPCSCSQSHCC TRWSAMGVMSLFLPCLWCYLPAKGC LKLCQGCYDRVNRPGCRCKNSNTVC CKVPTVPPRNFEKPTTRTRPLEQKL ISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
