| Description : |
This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 15 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to bind and endocytose ligands such as hyaluronan, low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein has been shown to cycle between the plasma membrane and lysosomes. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
276.99 kDa |
| AA Sequence : |
MMLQHLVIFCLGLVVQNFCSPAETT GQARRCDRKSLLTIRTECRSCALNL GVKCPDGYTMITSGSVGVRDCRYTF EVRTYSLSLPGCRHICRKDYLQPRC CPGRWGPDCIECPGGAGSPCNGRGS CAEGMEGNGTCSCQEGFGGTACETC ADDNLFGPSCSSVCNCVHGVCNSGL DGDGTCECYSAYTGPKCDKPIPECA ALLCPENSRCSPSTEDENKLECKCL PNYRGDGKYCDPINPCLRKICHPHA HCTYLGPNRHSCTCQEGYRGDGQVC LPVDPCQINFGNCPTKSTVCKYDGP GQSHCECKEHYQNFVPGVGCSMTDI CKSDNPCHRNANCTTVAPGRTECIC QKGYVGDGLTCYGNIMERLRELNTE PRGKWQGRLTSFISLLDKAYAWPLS KLGPFTVLLPTDKGLKGFNVNELLV DNKAAQYFVKLHIIAGQMNIEYMNN TDMFYTLTGKSGEIFNSDKDNQIKL KLHGGKKKVKIIQGDIIASNGLLHI LDRAMDKLEPTFESNNEQTIMTMLQ PRYSKFRSLLEETNLGHALDEDGVG GPYTIFVPNNEALNNMKDGTLDYLL SPEGSRKLLELVRYHIVPFTQLEVA TLISTPHIRSMANQLIQFNTTDNGQ ILANDVAMEEIEITAKNGRIYTLTG VLIPPSIVPILPHRCDETKREMKLG TCVSCSLVYWSRCPANSEPTALFTH RCVYSGRFGSLKSGCARYCNATVKI PKCCKGFYGPDCNQCPGGFSNPCSG NGQCADSLGGNGTCICEEGFQGSQC QFCSDPNKYGPRCNKKCLCVHGTCN NRIDSDGACLTGTCRDGSAGRLCDK QTSACGPYVQFCHIHATCEYSNGTA SCICKAGYEGDGTLCSEMDPCTGLT PGGCSRNAECIKTGTGTHTCVCQQG WTGNGRDCSEINNCLLPSAGGCHDN ASCLYVGPGQNECECKKGFRGNGID CEPITSCLEQTGKCHPLASCQSTSS GVWSCVCQEGYEGDGFLCYGNAAVE LSFLSEAAIFNRWINNASLQPTLSA TSNLTVLVPSQQATEDMDQDEKSFW LSQSNIPALIKYHMLLGTYRVADLQ TLSSSDMLATSLQGNFLHLAKVDGN ITIEGASIVDGDNAATNGVIHIINK VLVPQRRLTGSLPNLLMRLEQMPDY SIFRGYIIQYNLANAIEAADAYTVF APNNNAIENYIREKKVLSLEEDVLR YHVVLEEKLLKNDLHNGMHRETMLG FSYFLSFFLHNDQLYVNEAPINYTN VATDKGVIHGLGKVLEIQKNRCDNN DTTIIRGRCRTCSSELTCPFGTKSL GNEKRRCIYTSYFMGRRTLFIGCQP KCVRTVITRECCAGFFGPQCQPCPG NAQNVCFGNGICLDGVNGTGVCECG EGFSGTACETCTEGKYGIHCDQACS CVHGRCNQGPLGDGSCDCDVGWRGV HCDNATTEDNCNGTCHTSANCLTNS DGTASCKCAAGFQGNGTICTAINAC EISNGGCSAKADCKRTTPGRRVCTC KAGYTGDGIVCLEINPCLENHGGCD KNAECTQTGPNQAACNCLPAYTGDG KVCTLINVCLTKNGGCSEFAICNHT GQVERTCTCKPNYIGDGFTCRGSIY QELPKNPKTSQYFFQLQEHFVKDLV GPGPFTVFAPLSAAFDEEARVKDWD KYGLMPQVLRYHVVACHQLLLENLK LISNATSLQGEPIVISVSQSTVYIN NKAKIISSDIISTNGIVHIIDKLLS PKNLLITPKDNSGRILQNLTTLATN NGYIKFSNLIQDSGLLSVITDPIHT PVTLFWPTDQALHALPAEQQDFLFN QDNKDKLKEYLKFHVIRDAKVLAVD LPTSTAWKTLQGSELSVKCGAGRDI GDLFLNGQTCRIVQRELLFDLGVAY GIDCLLIDPTLGGRCDTFTTFDASG ECGSCVNTPSCPRWSKPKGVKQKCL YNLPFKRNLEGCRERCSLVIQIPRC CKGYFGRDCQACPGGPDAPCNNRGV CLDQYSATGECKCNTGFNGTACEMC WPGRFGPDCLPCGCSDHGQCDDGIT GSGQCLCETGWTGPSCDTQAVLPAV CTPPCSAHATCKENNTCECNLDYEG DGITCTVVDFCKQDNGGCAKVARCS QKGTKVSCSCQKGYKGDGHSCTEID PCADGLNGGCHEHATCKMTGPGKHK CECKSHYVGDGLNCEPEQLPIDRCL QDNGQCHADAKCVDLHFQDTTVGVF HLRSPLGQYKLTFDKAREACANEAA TMATYNQLSYAQKAKYHLCSAGWLE TGRVAYPTAFASQNCGSGVVGIVDY GPRPNKSEMWDVFCYRMKDVNCTCK VGYVGDGFSCSGNLLQVLMSFPSLT NFLTEVLAYSNSSARGRAFLEHLTD LSIRGTLFVPQNSGLGENETLSGRD IEHHLANVSMFFYNDLVNGTTLQTR LGSKLLITASQDPLQPTETRFVDGR AILQWDIFASNGIIHVISRPLKAPP APVTLTHTGLGAGIFFAIILVTGAV ALAAYSYFRINRRTIGFQHFESEED INVAALGKQQPENISNPLYESTTSA PPEPSYDPFTDSEERQLEGNDPLRT LTRTRPLEQKLISEEDLAANDILDY KDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
