| Description : |
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
85.9 kDa |
| AA Sequence : |
MSQWNQVQQLEIKFLEQVDQFYDDN FPMEIRHLLAQWIENQDWEAASNNE TMATILLQNLLIQLDEQLGRVSKEK NLLLIHNLKRIRKVLQGKFHGNPMH VAVVISNCLREERRILAAANMPVQG PLEKSLQSSSVSERQRNVEHKVAAI KNSVQMTEQDTKYLEDLQDEFDYRY KTIQTMDQSDKNSAMVNQEVLTLQE MLNSLDFKRKEALSKMTQIIHETDL LMNTMLIEELQDWKRRQQIACIGGP LHNGLDQLQNCFTLLAESLFQLRRQ LEKLEEQSTKMTYEGDPIPMQRTHM LERVTFLIYNLFKNSFVVERQPCMP THPQRPLVLKTLIQFTVKLRLLIKL PELNYQVKVKASIDKNVSTLSNRRF VLCGTNVKAMSIEESSNGSLSVEFR HLQPKEMKSSAGGKGNEGCHMVTEE LHSITFETQICLYGLTIDLETSSLP VVMISNVSQLPNAWASIIWYNVSTN DSQNLVFFNNPPPATLSQLLEVMSW QFSSYVGRGLNSDQLHMLAEKLTVQ SSYSDGHLTWAKFCKEHLPGKSFTF WTWLEAILDLIKKHILPLWIDGYVM GFVSKEKERLLLKDKMPGTFLLRFS ESHLGGITFTWVDHSESGEVRFHSV EPYNKGRLSALPFADILRDYKVIMA ENIPENPLKYLYPDIPKDKAFGKHY SSQPCEVSRPTERGDKGYVPSVFIP ISTIRSDSTEPHSPSDLLPMSPSVY AVLRENLSPTTIETAMKSPYSAETR TRPLEQKLISEEDLAANDILDYKDD DDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
