Recombinant Human STK4 Protein
Cat.No. : | STK4-6372H |
Product Overview : | Recombinant human STK4 protein without tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
- Download
Description : | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. |
Source : | E. coli |
Species : | Human |
Tag : | Tag Free |
Form : | Lyophilized powder/frozen liquid |
Purity : | > 90 % as determined by SDS-PAGE |
Notes : | For research use only. |
Storage : | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt. |
Storage Buffer : | Supplied as solution form in PBS, pH 7.5 or lyophilized from PBS, pH 7.5. |
Reconstitution : | Reconstitute in sterile water for a stock solution. |
Shipping : | They are shipped out with dry ice/blue ice unless customers require otherwise. |
Gene Name : | STK4 serine/threonine kinase 4 [ Homo sapiens (human) ] |
Official Symbol : | STK4 |
Synonyms : | STK4; serine/threonine kinase 4; serine/threonine-protein kinase 4; kinase responsive to stress 2; KRS2; mammalian sterile 20 like 1; MST1; yeast Ste20 like; YSK3; MST-1; STE20-like kinase MST1; mammalian sterile 20-like 1; mammalian STE20-like protein kinase 1; serine/threonine-protein kinase Krs-2; dJ211D12.2 (serine/threonine kinase 4 (MST1, KRS2)); DKFZp686A2068; |
Gene ID : | 6789 |
mRNA Refseq : | NM_006282 |
Protein Refseq : | NP_006273 |
MIM : | 604965 |
UniProt ID : | Q13043 |
Products Types
◆ Recombinant Protein | ||
STK4-2127H | Recombinant Human STK4 Protein, His (Fc)-Avi-tagged | +Inquiry |
STK4-1233H | Recombinant Human STK4 Protein (E2-E311), Tag Free | +Inquiry |
STK4-2841H | Recombinant Human STK4 protein(301-480 aa), C-His-tagged | +Inquiry |
STK4-2960H | Recombinant Human STK4 Protein, MYC/DDK-tagged | +Inquiry |
STK4-1234H | Recombinant Human STK4 Protein (E2-E311), His tagged | +Inquiry |
◆ Lysates | ||
STK4-604HCL | Recombinant Human STK4 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (0)
Ask a questionAsk a Question for All STK4 Products
Required fields are marked with *
My Review for All STK4 Products
Required fields are marked with *
0
Inquiry Basket