| Description : |
SUN1 and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
80.1 kDa |
| AA Sequence : |
MSRRSQRLTRYSQGDDDGSSSSGGS SVAGSQSTLFKDSPLRTLKRKSSNM KRLSPAPQLGPSSDAHTSYYSESLV HESWFPPRSSLEELHGDANWGEDLR VRRRRGTGGSESSRASGLVGRKATE DFLGSSSGYSSEDDYVGYSDVDQQS SSSRLRSAVSRAGSLLWMVATSPGR LFRLLYWWAGTTWYRLTTAASLLDV FVLTRRFSSLKTFLWFLLPLLLLTC LTYGAWYFYPYGLQTFHPALVSWWA AKDSRRPDEGWEARDSSPHFQAEQR VMSRVHSLERRLEALAAEFSSNWQK EAMRLERLELRQGAPGQGGGGGLSH EDTLALLEGLVSRREAALKEDFRRE TAARIQEELSALRAEHQQDSEDLFK KIVRASQESEARIQQLKSEWQSMTQ ESFQESSVKELRRLEDQLAGLQQEL AALALKQSSVAEEVGLLPQQIQAVR DDVESQFPAWISQFLARGGGGRVGL LQREEMQAQLRELESKILTHVAEMQ GKSAREAAASLSLTLQKEGVIGVTE EQVHHIVKQALQRYSEDRIGLADYA LESGGASVISTRCSETYETKTALLS LFGIPLWYHSQSPRVILQPDVHPGN CWAFQGPQGFAVVRLSARIRPTAVT LEHVPKALSPNSTISSAPKDFAIFG FDEDLQQEGTLLGKFTYDQDGEPIQ TFHFQAPTMATYQVVELRILTNWGH PEYTCIYRFRVHGEPAHTRTRPLEQ KLISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
