Recombinant Human Superoxide Dismutase 1, Soluble, GST-tagged

• Cat.No.: SOD1-1635H
• Product Overview: Recombinant full-length human SOD1 was expressed in E. coli cells using an N-terminal GST tag.

Specification

• Cat. No.: SOD1-1635H
• Description: SOD1 (superoxide dismutase 1) is the major soluble cytoplasmic enzyme responsible for destroying harmful free superoxide radicals in the body thereby providing defence against oxygen free-radical toxicity. Soluble cytoplasmic SOD1 is a copper- and zinc-containing enzyme and the SOD1 gene maps to chromosome 21q22. Mutations in the SOD1 gene have been implicated to be the cause of familial amyotrophic lateral sclerosis, increased age-related muscle mass loss, early development of cataracts, macular degeneration, thymic involution, hepatocellular carcinoma, and shortned lifespan.
• Applications: Western Blot
• Molecular Weight: 45 kDa
• Expression System: E. coli
• Species: Human
• Form: Recombinant protein stored in 50 mM Tris-HCL, pH 7.5, 150 mM NaCl, 0.1 mM PMSF, 0.25 mM DTT, 10 mM gluthione, 0.1 mM EDTA, 25 % glycerol.
• Purity: > 90 %
• Concentration: 0.2 ug/ul
• Sequences: Full-length
• Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Pathways: Amyotrophic lateral sclerosis (ALS); Huntington"s disease; Prion diseases; Hemostasis

Gene Information

• Gene Name: SOD1 superoxide dismutase 1, soluble [ Homo sapiens ]
• Official Symbol: SOD1
• Synonyms: SOD1; superoxide dismutase 1, soluble; ALS; SOD; ALS1; IPOA; homodimer; SOD, soluble; indophenoloxidase A; Cu/Zn superoxide dismutase; superoxide dismutase, cystolic; EC 1.15.1.1; Superoxide dismutase [Cu-Zn]
• Gene ID: 6647
• mRNA Refseq: NM_000454
• Protein Refseq: NP_000445
• MIM: 147450
• UniProt ID: P00441
• Chromosome Location: 21q22.11
• Function: antioxidant activity; chaperone binding; copper ion binding; metal ion binding; protein homodimerization activity; protein phosphatase 2B binding; superoxide dismutase activity; zinc ion binding

Reviews

11/15/2022

Worked perfectly, no problems.

10/09/2020

Quick delivery, fantastic product.

10/02/2020

Reliable results every time.

Q&As

Are there potential therapeutic strategies targeting SOD1 for disease treatment?

Therapeutic strategies may involve modulating SOD1 activity or expression to mitigate oxidative stress-related damage.

What is the primary biological function of SOD1 in cells?

SOD1 acts as an antioxidant, converting superoxide radicals to hydrogen peroxide and oxygen.

What are the genetic implications of mutations in the SOD1 gene?

Mutations in SOD1 can result in loss or gain of function, contributing to disease development.

How is SOD1 implicated in neurodegenerative diseases?

SOD1 mutations are implicated in Amyotrophic Lateral Sclerosis (ALS), leading to neurodegeneration.

In which cellular compartments is SOD1 primarily located?

SOD1 is primarily located in the cytoplasm and mitochondrial intermembrane space.

What role does SOD1 play in maintaining cellular redox balance?

It helps maintain cellular redox balance, protecting cells from oxidative damage.

How does SOD1 contribute to the cellular antioxidant defense system?

It plays a crucial role in cellular defense against oxidative stress.