| Description : |
This gene encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
141 kDa |
| AA Sequence : |
MASGSGDSVTRRSVASQFFTQEEGP GIDGMTTSERVVDLLNQAALITNDS KITVLKQVQELIINKDPTLLDNFLD EIIAFQADKSIEVRKFVIGFIEEAC KRDIELLLKLIANLNMLLRDENVNV VKKAILTMTQLYKVALQWMVKSRVI SELQEACWDMVSAMAGDIILLLDSD NDGIRTHAIKFVEGLIVTLSPRMAD SEIPRRQEHDISLDRIPRDHPYIQY NVLWEEGKAALEQLLKFMVHPAISS INLTTALGSLANIARQRPMFMSEVI QAYETLHANLPPTLAKSQVSSVRKN LKLHLLSVLKHPASLEFQAQITTLL VDLGTPQAEIARNMPSSKDTRKRPR DDSDSTLKKMKLEPNLGEDDEDKDL EPGPSGTSKASAQISGQSDTDITAE FLQPLLTPDNVANLVLISMVYLPEA MPASFQAIYTPVESAGTEAQIKHLA RLMATQMTAAGLGPGVEQTKQCKEE PKEEKVVKTESVLIKRRLSAQGQAI SVVGSLSSMSPLEEEAPQAKRRPEP IIPVTQPRLAGAGGRKKIFRLSDVL KPLTDAQVEAMKLGAVKRILRAEKA VACSGAAQVRIKILASLVTQFNSGL KAEVLSFILEDVRARLDLAFAWLYQ EYNAYLAAGASGSLDKYEDCLIRLL SGLQEKPDQKDGIFTKVVLEAPLIT ESALEVVRKYCEDESRTYLGMSTLR DLIFKRPSRQFQYLHVLLDLSSHEK DKVRSQALLFIKRMYEKEQLREYVE KFALNYLQLLVHPNPPSVLFGADKD TEVAAPWTEETVKQCLYLYLALLPQ NHKLIHELAAVYTEAIADIKRTVLR VIEQPIRGMGMNSPELLLLVENCPK GAETLVTRCLHSLTDKVPPSPELVK RVRDLYHKRLPDVRFLIPVLNGLEK KEVIQALPKLIKLNPIVVKEVFNRL LGTQHGEGNSALSPLNPGELLIALH NIDSVKCDMKSIIKATNLCFAERNV YTSEVLAVVMQQLMEQSPLPMLLMR TVIQSLTMYPRLGGFVMNILSRLIM KQVWKYPKVWEGFIKCCQRTKPQSF QVILQLPPQQLGAVFDKCPELREPL LAHVRSFTPHQQAHIPNSIMTILEA SGKQEPEAKEAPAGPLEEDDLEPLT LAPAPAPRPPQDLIGLRLAQEKALK RQLEEEQKLKPGGVGAPSSSSPSPS PSARPGPPPSEEAMDFREEGPECET PGIFISMDDDSGLTEAALLDSSLEG PLPKETAAGGLTLKEERSPQTLAPV GEDAMKTPSPAAEDAREPEAKGNST RTRPLEQKLISEEDLAANDILDYKD DDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
