Recombinant Human TAOK2 Protein (M1-K314), GST tagged
Cat.No. : | TAOK2-1116H |
Product Overview : | Recombinant Human GST-TEV-TAOK2(M1-K314) Protein was expressed in Insect cell. |
- Specification
- Gene Information
- Related Products
Description : | Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation. |
Source : | Insect cell |
Species : | Human |
Tag : | GST |
Form : | Liquid |
Protein Length : | M1-K314 |
Endotoxin : | < 0.01 EU per μg of the protein |
Purity : | 90% |
Stability : | Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. |
Storage : | Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol |
Shipping : | It is shipped out with blue ice. |
Gene Name : | TAOK2 TAO kinase 2 [ Homo sapiens (human) ] |
Official Symbol : | TAOK2 |
Synonyms : | TAOK2; TAO kinase 2; serine/threonine-protein kinase TAO2; KIAA0881; MAP3K17; PSK; PSK1; TAO1; TAO2; PSK-1; hKFC-C; kinase from chicken homolog C; prostate-derived STE20-like kinase 1; prostate derived STE20-like kinase PSK; prostate-derived sterile 20-like kinase 1; thousand and one amino acid protein kinase 2; PSK1-BETA; |
Gene ID : | 9344 |
mRNA Refseq : | NM_001252043 |
Protein Refseq : | NP_001238972 |
MIM : | 613199 |
UniProt ID : | Q9UL54 |
Products Types
◆ Recombinant Protein | ||
TAOK2-5584R | Recombinant Rat TAOK2 Protein, His (Fc)-Avi-tagged | +Inquiry |
TAOK2-1117H | Recombinant Human TAOK2 Protein (M1-K314), Tag Free | +Inquiry |
TAOK2-8984M | Recombinant Mouse TAOK2 Protein, His (Fc)-Avi-tagged | +Inquiry |
Taok2-6290M | Recombinant Mouse Taok2 Protein, Myc/DDK-tagged | +Inquiry |
TAOK2-3111H | Recombinant Human TAOK2, GST-tagged | +Inquiry |
◆ Lysates | ||
TAOK2-1255HCL | Recombinant Human TAOK2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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