| Description : |
Acts as GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
103.9 kDa |
| AA Sequence : |
MEGAGENAPESSSSAPGSEESARDP QVPPPEEESGDCARSLEAVPKKLCG YLSKFGGKGPIRGWKSRWFFYDERK CQLYYSRTAQDANPLDSIDLSSAVF DCKADAEEGIFEIKTPSRVITLKAA TKQAMLYWLQQLQMKRWEFHNSPPA PPATPDAALAGNGPVLHLELGQEEA ELEEFLCPVKTPPGLVGVAAALQPF PALQNISLKHLGTEIQNTMHNIRGN KQAQGTGHEPPGEDSPQSGEPQREE QPLASDASTPGREPEDSPKPAPKPS LTISFAQKAKRQNNTFPFFSEGITR NRTAQEKVAALEQQVLMLTKELKSQ KELVKILHKALEAAQQEKRASSAYL AAAEDKDRLELVRHKVRQIAELGRR VEALEQERESLAHTASLREQQVQEL QQHVQLLMDKNHAKQQVICKLSEKV TQDFTHPPDQSPLRPDAANRDFLSQ QGKIEHLKDDMEAYRTQNCFLNSEI HQVTKIWRKVAEKEKALLTKCAYLQ ARNCQVESKYLAGLRRLQEALGDEA SECSELLRQLVQEALQWEAGEASSD SIELSPISKYDEYGFLTVPDYEVED LKLLAKIQALESRSHHLLGLEAVDR PLRERWAALGDLVPSAELKQLLRAG VPREHRPRVWRWLVHLRVQHLHTPG CYQELLSRGQAREHPAARQIELDLN RTFPNNKHFTCPTSSFPDKLRRVLL AFSWQNPTIGYCQGLNRLAAIALLV LEEEESAFWCLVAIVETIMPADYYC NTLTASQVDQRVLQDLLSEKLPRLM AHLGQHHVDLSLVTFNWFLVVFADS LISNILLRVWDAFLYEGTKYNEKEI LRLQNGLEIYQYLRFFTKTISNSRK LMNIAFNDMNPFRMKQLRQLRMVHR ERLEAELRELEQLKAEYLERRASRR RAVSEGCASEDEVEGEATRTRPLEQ KLISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
