| Description : |
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene were found in patients with isolated deficiency of pituitary POMC-derived ACTH, suggesting an essential role for this gene in differentiation of the pituitary POMC lineage. ACTH deficiency is characterized by adrenal insufficiency symptoms such as weight loss, lack of appetite (anorexia), weakness, nausea, vomiting, and low blood pressure. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
48.2 kDa |
| AA Sequence : |
MAMSELGTRKPSDGTVSHLLNVVES ELQAGREKGDPTEKQLQIILEDAPL WQRFKEVTNEMIVTKNGRRMFPVLK ISVTGLDPNAMYSLLLDFVPTDSHR WKYVNGEWVPAGKPEVSSHSCVYIH PDSPNFGAHWMKAPISFSKVKLTNK LNGGGQIMLNSLHKYEPQVHIVRVG SAHRMVTNCSFPETQFIAVTAYQNE EITALKIKYNPFAKAFLDAKERNHL RDVPEAISESQHVTYSHLGGWIFSN PDGVCTAGNSNYQYAAPLPLPAPHT HHGCEHYSGLRGHRQAPYPSAYMHR NHSPSVNLIESSSNNLQVFSGPDSW TSLSSTPHASILSVPHTNGPINPGP SPYPCLWTISNGAGGPSGPGPEVHA STPGAFLLGNPAVTSPPSVLSTQAP TSAGVEVLGEPSLTSIAVSTWTAVA SHPFAGWGGPGAGGHHSPSSLDGTR TRPLEQKLISEEDLAANDILDYKDD DDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
