| Description : |
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
58.1 kDa |
| AA Sequence : |
MGIVEPGCGDMLTGTEPMPGSDEGR APGADPQHRYFYPEPGAQDADERRG GGSLGSPYPGGALVPAPPSRFLGAY AYPPRPQAAGFPGAGESFPPPADAE GYQPGEGYAAPDPRAGLYPGPREDY ALPAGLEVSGKLRVALNNHLLWSKF NQHQTEMIITKQGRRMFPFLSFTVA GLEPTSHYRMFVDVVLVDQHHWRYQ SGKWVQCGKAEGSMPGNRLYVHPDS PNTGAHWMRQEVSFGKLKLTNNKGA SNNVTQMIVLQSLHKYQPRLHIVEV NDGEPEAACNASNTHIFTFQETQFI AVTAYQNAEITQLKIDNNPFAKGFR ENFESMYTSVDTSIPSPPGPNCQFL GGDHYSPLLPNQYPVPSRFYPDLPG QAKDVVPQAYWLGAPRDHSYEAEFR AVSMKPAFLPSAPGPTMSYYRGQEV LAPGAGWPVAPQYPPKMGPASWFRP MRTLPMEPGPGGSEGRGPEDQGPPL VWTEIAPIRPESSDSGLGEGDSKRR RVSPYPSSGDSSSPAGAPSPFDKEA EGQFYNYFPNTRTRPLEQKLISEED LAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
