Recombinant Human TDO2 protein, His-tagged
Cat.No. : | TDO2-724H |
Product Overview : | Recombinant Human TDO2(2-406 aa) fused with His tag at N-terminal was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween 20, 20% glycerol, 440 mM Imidazole |
Molecular Mass : | 49 kDa |
Purity : | >92% |
Applications : | Useful for studying enzyme kinetics, substrate specificity, and screening inhibitors. |
Storage : | At least 6 months at –80 centigrade. Avoid freeze/thaw cycles. Storing diluted enzyme is not recommended, if necessary, use carrier protein (BSA 0.1 – 0.5%). |
Concentration : | 0.65 mg/ml |
Gene Name : | TDO2 tryptophan 2,3-dioxygenase [ Homo sapiens ] |
Official Symbol : | TDO2 |
Synonyms : | TDO2; tryptophan 2,3-dioxygenase; TDO; TPH2; tryptophanase; tryptophan oxygenase; tryptophan pyrrolase; tryptamin 2,3-dioxygenase; TO; TRPO; |
Gene ID : | 6999 |
mRNA Refseq : | NM_005651 |
Protein Refseq : | NP_005642 |
MIM : | 191070 |
UniProt ID : | P48775 |
Chromosome Location : | 4q31-q32 |
Pathway : | Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of amino acids and derivatives, organism-specific biosystem; Monoamine Transport, organism-specific biosystem; NAD biosynthesis II (from tryptophan), organism-specific biosystem; NAD biosynthesis II (from tryptophan), conserved biosystem; Tryptophan catabolism, organism-specific biosystem; |
Function : | amino acid binding; heme binding; metal ion binding; oxidoreductase activity; oxygen binding; tryptophan 2,3-dioxygenase activity; |
Products Types
◆ Recombinant Protein | ||
TDO2-1958R | Recombinant Rat TDO2 Protein (1-406 aa), His-SUMO-tagged | +Inquiry |
TDO2-1535H | Recombinant Human TDO2 Protein (1-406 aa), His-tagged | +Inquiry |
TDO2-4170H | Recombinant Human TDO2 Protein, His (Fc)-Avi-tagged | +Inquiry |
TDO2-5656R | Recombinant Rat TDO2 Protein, His (Fc)-Avi-tagged | +Inquiry |
TDO2-9103M | Recombinant Mouse TDO2 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
TDO2-1156HCL | Recombinant Human TDO2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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