Recombinant human TEA domain transcription factor 1 protein, His-tagged
Cat.No. : | TEAD1-01H |
Product Overview : | Recombinant human TEA domain transcription factor 1 with N-terminal His6 fusion tag was expressed in E. coli. |
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Description : | Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Buffered aqueous solution |
Molecular Mass : | 28.6 kDa |
Protein length : | 246 |
AA Sequence : | MHHHHHHLVPRGSGLNDIFEAQKIE WHERSIGTTKLRLVEFSAFLEQQRD PDSYNKHLFVHIGHANHSYSDPLLE SVDIRQIYDKFPEKKGGLKELFGKG PQNAFFLVKFWADLNCNIQDDAGAF YGVTSQYESSENMTVTCSTKVCSFG KQVVEKVETEYARFENGRFVYRINR SPMCEYMINFIHKLKHLPEKYMMNS VLENFTILLVVTNRDTQETLLCMAC VFEVSNSEHGAQHHIYRLVKD |
Purity : | >90% by SDS-PAGE |
Applications : | Antigen for antibody production ELISA WB |
Storage : | Store it under sterile conditions at -20 to -80 ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Concentration : | 0.292 mg/ml |
Storage Buffer : | Solution in 50mM Tris, 300mM NaCl, pH8.0, 0.1% SKL |
Gene Name : | TEAD1 |
Official Symbol : | TEAD1 |
Synonyms : | AA; Atrophia areata peripapillary chorioretinal degeneration; NTEF 1; NTEF-1; NTEF1; REF1; SV40 transcriptional enhancer factor; TCF 13; TCF-13; TCF13; TEA domain family member |
Gene ID : | 7003 |
mRNA Refseq : | NM_021961.6 |
Protein Refseq : | NP_068780.2 |
UniProt ID : | P28347 |
Products Types
◆ Recombinant Protein | ||
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TEAD1-2756H | Recombinant Human TEAD1 Protein, His-tagged | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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