Recombinant Human TEC Protein (N2-R631), Tag Free
Cat.No. : | TEC-0748H |
Product Overview : | Recombinant Human GG-TEC(N2-R631 end) Protein was expressed in Insect cell. |
- Specification
- Gene Information
- Related Products
Description : | Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth, differentiation, and functional activation of myeloid cells. Participates in platelet signaling downstream of integrin activation. Cooperates with JAK2 through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. GRB10, a negative modifier of the FOS activation pathway, is another substrate of TEC. TEC is involved in G protein-coupled receptor- and integrin-mediated signalings in blood platelets. Plays a role in hepatocyte proliferation and liver regeneration and is involved in HGF-induced ERK signaling pathway. TEC regulates also FGF2 unconventional secretion (endoplasmic reticulum (ER)/Golgi-independent mechanism) under various physiological conditions through phosphorylation of FGF2 'Tyr-215'. May also be involved in the regulation of osteoclast differentiation. |
Source : | Insect cell |
Species : | Human |
Tag : | No tag |
Form : | Liquid |
Protein Length : | N2-R631 |
Endotoxin : | < 0.01 EU per μg of the protein |
Purity : | 90% |
Stability : | Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. |
Storage : | Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol |
Shipping : | It is shipped out with blue ice. |
Gene Name : | TEC tec protein tyrosine kinase [ Homo sapiens (human) ] |
Official Symbol : | TEC |
Synonyms : | TEC; tec protein tyrosine kinase; tyrosine-protein kinase Tec; PSCTK4; MGC126760; MGC126762; |
Gene ID : | 7006 |
mRNA Refseq : | NM_003215 |
Protein Refseq : | NP_003206 |
MIM : | 600583 |
UniProt ID : | P42680 |
Products Types
◆ Recombinant Protein | ||
TEC-0747H | Recombinant Human TEC Protein (N2-R631), GST tagged | +Inquiry |
TEC-9117M | Recombinant Mouse TEC Protein, His (Fc)-Avi-tagged | +Inquiry |
TEC-2240C | Recombinant Chicken TEC | +Inquiry |
TEC-6479Z | Recombinant Zebrafish TEC | +Inquiry |
Tec-8070M | Recombinant Mouse Tec protein, His & T7-tagged | +Inquiry |
◆ Lysates | ||
TEC-1153HCL | Recombinant Human TEC 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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