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Recombinant Human TFCP2L1 Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : TFCP2L1-3236H
Product Overview : TFCP2L1 MS Standard C13 and N15-labeled recombinant protein (NP_055368) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
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Description : Transcription factor that facilitates establishment and maintenance of pluripotency in embryonic stem cells (ESCs). With KLF2, acts as the major effector of self-renewal that mediates induction of pluripotency downstream of LIF/STAT3 and Wnt/beta-catenin signaling. Required for normal duct development in the salivary gland and kidney. Coordinates the development of the kidney collecting ducts intercalated (IC) and principal (PC) cells, which regulate acid-base and salt-water homeostasis, respectively. Regulates the expression of IC genes including subunits B1 and D2 of the V-ATPase complex, OXGR1, CA12, SLC4A1, AQP6 and IC-specific transcription factor FOXI1. Regulates also the expression of JAG1 and subsequent notch signaling in the collecting duct. JAG1 initiates notch signaling in PCs but inhibits notch signaling in ICs. Acts as a transcriptional suppressor that may suppress UBP1-mediated transcriptional activation. Modulates the placental expression of CYP11A1.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 54.4 kDa
AA Sequence : MLFWHTQPEHYNQHNSGSYLRDVLA LPIFKQEEPQLSPENEARLPPLQYV LCAATSPAVKLHEETLTYLNQGQSY EIRLLENRKLGDFQDLNTKYVKSII RVVFHDRRLQYTEHQQLEGWRWSRP GDRILDIDIPLSVGILDPRASPTQL NAVEFLWDPAKRASAFIQVHCISTE FTPRKHGGEKGVPFRVQIDTFKQNE NGEYTEHLHSASCQIKVFKPKGADR KQKTDREKMEKRTAQEKEKYQPSYE TTILTECSPWPDVAYQVNSAPSPSY NGSPNSFGLGEGNASPTHPVEALPV GSDHLLPSASIQDAQQWLHRNRFSQ FCRLFASFSGADLLKMSRDDLVQIC GPADGIRLFNAIKGRNVRPKMTIYV CQELEQNRVPLQQKRDGSGDSNLSV YHAIFLEELTTLELIEKIANLYSIS PQHIHRVYRQGPTGIHVVVSNEMVQ NFQDESCFVLSTIKAESNDGYHIIL KCGLTRTRPLEQKLISEEDLAANDI LDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : TFCP2L1 transcription factor CP2-like 1 [ Homo sapiens (human) ]
Official Symbol : TFCP2L1
Synonyms : TFCP2L1; transcription factor CP2-like 1; transcription factor CP2-like protein 1; CRTR1; LBP 9; CRTR-1; transcription factor LBP-9; CP2-related transcriptional repressor 1; LBP9; LBP-9;
Gene ID : 29842
mRNA Refseq : NM_014553
Protein Refseq : NP_055368
MIM : 609785
UniProt ID : Q9NZI6

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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