| Description : |
This gene encodes a protein component of the spliceosome that promotes the release of the lariat-intron during late-stage splicing through the recruitment of a pre-mRNA splicing factor called DEAH-box helicase 15. The encoded protein contains a G-patch domain, a hallmark of RNA-processing proteins, that binds DEAH-box helicase 15. This protein contains an atypical nuclear localization sequence as well as a nuclear speckle-targeting sequence, enabling it to localize to distinct speckled regions within the cell nucleus. Polymorphisms in this gene are associated with dental caries suggesting a role in amelogenesis. Alternative splicing results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
96.8 kDa |
| AA Sequence : |
MSLSHLYRDGEGRIDDDDDERENFE ITDWDLQNEFNPNRQRHWQTKEEAT YGVWAERDSDDERPSFGGKRARDYS APVNFISAGLKKGAAEEAELEDSDD EEKPVKQDDFPKDFGPRKLKTGGNF KPSQKGFAGGTKSFMDFGSWERHTK GIGQKLLQKMGYVPGRGLGKNAQGI INPIEAKQRKGKGAVGAYGSERTTQ SMQDFPVVDSEEEAEEEFQKELSQW RKDPSGSKKKPKYSYKTVEELKAKG RISKKLTAPQKELSQVKVIDMTGRE QKVYYSYSQISHKHNVPDDGLPLQS QQLPQSGKEAKAPGFALPELEHNLQ LLIDLTEQEIIQNDRQLQYERDMVV NLFHELEKMTEVLDHEERVISNLSK VLEMVEECERRMQPDCSNPLTLDEC ARIFETLQDKYYEEYRMSDRVDLAV AIVYPLMKEYFKEWDPLKDCTYGTE IISKWKSLLENDQLLSHGGQDLSAD AFHRLIWEVWMPFVRNIVTQWQPRN CDPMVDFLDSWVHIIPVWILDNILD QLIFPKLQKEVENWNPLTDTVPIHS WIHPWLPLMQARLEPLYSPIRSKLS SALQKWHPSDSSAKLILQPWKDVFT PGSWEAFMVKNIVPKLGMCLGELVI NPHQQHMDAFYWVIDWEGMISVSSL VGLLEKHFFPKWLQVLCSWLSNSPN YEEITKWYLGWKSMFSDQVLAHPSV KDKFNEALDIMNRAVSSNVGAYMQP GARENIAYLTHTERRKDFQYEAMQE RREAENMAQRGIGVAASSVPMNFKD LIETKAEEHNIVFMPVIGKRHEGKQ LYTFGRIVIYIDRGVVFVQGEKTWV PTSLQSLIDMAKTRTRPLEQKLISE EDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
