| Description : |
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Tag Free |
| Protein length : |
Mature chain |
| Conjugation/Label : |
Biotin |
| Form : |
Lyophilised |
| Endotoxin : |
Endotoxin level was found to be less than 0.1 ng/μg (1 EU/μg). |
| Notes : |
FOR RESEARCH USE ONLY (RUO). |
| Storage : |
Upon reconstitution, this cytokine can be stored in working aliquots at 2 to 8 centigrade for one month, or at -20 centigrade for six months. Avoid repeated freeze/thaw cycles. |
| Storage Buffer : |
Lyophilised from 0.2 μm filtered PBS solution pH 7.4. |
| Reconstitution : |
Upon receipt a quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. |
