Recombinant Human THRA Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: THRA-1945H
• Product Overview: THRA MS Standard C13 and N15-labeled recombinant protein (NP_003241) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 54.8 kDa
• AA Sequence: MEQKPSKVECGSDPEENSARSPDGK RKRKNGQCSLKTSMSGYIPSYLDKD EQCVVCGDKATGYHYRCITCEGCKG FFRRTIQKNLHPTYSCKYDSCCVID KITRNQCQLCRFKKCIAVGMAMDLV LDDSKRVAKRKLIEQNRERRRKEEM IRSLQQRPEPTPEEWDLIHIATEAH RSTNAQGSHWKQRRKFLPDDIGQSP IVSMPDGDKVDLEAFSEFTKIITPA ITRVVDFAKKLPMFSELPCEDQIIL LKGCCMEIMSLRAAVRYDPESDTLT LSGEMAVKREQLKNGGLGVVSDAIF ELGKSLSAFNLDDTEVALLQAVLLM STDRSGLLCVDKIEKSQEAYLLAFE HYVNHRKHNIPHFWPKLLMKEREVQ SSILYKGAAAEGRPGGSLGVHPEGQ QLLGMHVVQGPQVRQLEQQLGEAGS LQGPVLQHQSPKSPQQRLLELLHRS GILHARAVCGEDDSSEADSPSSSEE EPEVCEDLAGNAASPTRTRPLEQKL ISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: THRA thyroid hormone receptor alpha [ Homo sapiens (human) ]
• Official Symbol: THRA
• Synonyms: THRA; thyroid hormone receptor alpha; AR7; EAR7; ERBA; CHNG6; ERBA1; NR1A1; THRA1; THRA2; ERB-T-1; c-ERBA-1; thyroid hormone receptor alpha; EAR-7; ERBA-related 7; V-erbA-related protein 7; c-erbA-alpha; nuclear receptor subfamily 1 group A member 1; thyroid hormone receptor alpha 1; thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian); thyroid normone nuclear receptor alpha variant 1; triiodothyronine receptor
• Gene ID: 7067
• mRNA Refseq: NM_003250
• Protein Refseq: NP_003241
• MIM: 190120
• UniProt ID: P10827