Recombinant Human TK2 Protein, His-tagged

• Cat.No.: TK2-914H
• Product Overview: Recombinant Human TK2, transcript variant 1, fused with His tag at N-terminal was expressed in E. coli.

Specification

• Description: This gene encodes a deoxyribonucleoside kinase that specifically phosphorylates thymidine, deoxycytidine, and deoxyuridine. The encoded enzyme localizes to the mitochondria and is required for mitochondrial DNA synthesis. Mutations in this gene are associated with a myopathic form of mitochondrial DNA depletion syndrome. Alternate splicing results in multiple transcript variants encoding distinct isoforms, some of which lack transit peptide, so are not localized to mitochondria.
• Source: E. coli
• Tag: His
• Form: 50mM Tris, 8M Urea, pH8.0.
• Molecular Mass: 27.4 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: TK2 thymidine kinase 2, mitochondrial [ Homo sapiens ]
• Official Symbol: TK2
• Synonyms: TK2; thymidine kinase 2, mitochondrial; mt-TK; MTTK; MTDPS2
• Gene ID: 7084
• mRNA Refseq: NM_001172643
• Protein Refseq: NP_001166114
• MIM: 188250
• UniProt ID: O00142