| Description : |
This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
97.77 kDa |
| AA Sequence : |
MGDHLDLLLGVVLMAGPVFGIPSCS FDGRIAFYRFCNLTQVPQVLNTTER LLLSFNYIRTVTASSFPFLEQLQLL ELGSQYTPLTIDKEAFRNLPNLRIL DLGSSKIYFLHPDAFQGLFHLFELR LYFCGLSDAVLKDGYFRNLKALTRL DLSKNQIRSLYLHPSFGKLNSLKSI DFSSNQIFLVCEHELEPLQGKTLSF FSLAANSLYSRVSVDWGKCMNPFRN MVLEILDVSGNGWTVDITGNFSNAI SKSQAFSLILAHHIMGAGFGFHNIK DPDQNTFAGLARSSVRHLDLSHGFV FSLNSRVFETLKDLKVLNLAYNKIN KIADEAFYGLDNLQVLNLSYNLLGE LYSSNFYGLPKVAYIDLQKNHIAII QDQTFKFLEKLQTLDLRDNALTTIH FIPSIPDIFLSGNKLVTLPKINLTA NLIHLSENRLENLDILYFLLRVPHL QILILNQNRFSSCSGDQTPSENPSL EQLFLGENMLQLAWETELCWDVFEG LSHLQVLYLNHNYLNSLPPGVFSHL TALRGLSLNSNRLTVLSHNDLPANL EILDISRNQLLAPNPDVFVSLSVLD ITHNKFICECELSTFINWLNHTNVT IAGPPADIYCVYPDSLSGVSLFSLS TEGCDEEEVLKSLKFSLFIVCTVTL TLFLMTILTVTKFRGFCFICYKTAQ RLVFKDHPQGTEPDMYKYDAYLCFS SKDFTWVQNALLKHLDTQYSDQNRF NLCFEERDFVPGENRIANIQDAIWN SRKIVCLVSRHFLRDGWCLEAFSYA QGRCLSDLNSALIMVVVGSLSQYQL MKHQSIRGFVQKQQYLRWPEDLQDV GWFLHKLSQQILKKEKEKKKDNNIP LQTVATISTRTRPLEQKLISEEDLA ANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
