| Description : |
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The canonical protein encoded by this gene has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, one transmembrane domain and a C-terminal ER-retention sequence. This gene is expressed in many tissues but has its highest expression in heart and skeletal muscle. It is expressed in the retinal neuroepithelium and lens epithelium in the developing murine eye and haploinsufficiency of this gene in humans and zebrafish is associated with microphthalmia. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
51.9 kDa |
| AA Sequence : |
MAAWKSWTALRLCATVVVLDMVVCK GFVEDLDESFKENRNDDIWLVDFYA PWCGHCKKLEPIWNEVGLEMKSIGS PVKVGKMDATSYSSIASEFGVRGYP TIKLLKGDLAYNYRGPRTKDDIIEF AHRVSGALIRPLPSQQMFEHMQKRH RVFFVYVGGESPLKEKYIDAASELI VYTYFFSASEEVVPEYVTLKEMPAV LVFKDETYFVYDEYEDGDLSSWINR ERFQNYLAMDGFLLYELGDTGKLVA LAVIDEKNTSVEHTRLKSIIQEVAR DYRDLFHRDFQFGHMDGNDYINTLL MDELTVPTVVVLNTSNQQYFLLDRQ IKNVEDMVQFINNILDGTVEAQGGD SILQRLKRIVFDAKSTIVSIFKSSP LMGCFLFGLPLGVISIMCYGIYTAD TDGGYIEERYEVSKSENENQEQIEE SKEQQEPSSGGSVVPTVQEPKDVLE KKKDTRTRPLEQKLISEEDLAANDI LDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
