Recombinant Human TNC protein(Gly23-Ser621), His-tagged

• Cat.No.: TNC-735H
• Product Overview: Recombinant Human TNC protein(Gly23-Ser621)(P24821-1) is expressed from HEK293 with His tag at the C-Terminus.

Specification

• Source: HEK293
• Species: Human
• Tag: C-His
• Protein length: Gly23-Ser621
• Form: Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
• Molecular Mass: The protein has a predicted MW of 65.27 kDa. Due to glycosylation, the protein migrates to 66-70 kDa based on Tris-Bis PAGE result.
• Endotoxin: Less than 1EU per μg by the LAL method.
• Purity: > 95% as determined by Tris-Bis PAGE
  > 95% as determined by HPLC
• Storage: -20 to -80°C for 12 months as supplied from date of receipt.
  -80°C for 3-6 months after reconstitution.
  2-8°C for 2-7 days after reconstitution.
  Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
• Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

Gene Information

• Gene Name: TNC tenascin C [ Homo sapiens ]
• Official Symbol: TNC
• Synonyms: TNC; tenascin C; hexabrachion (tenascin C, cytotactin) , HXB; tenascin; hexabrachion (tenascin); MGC167029; TN; GP 150-225; cytotactin; neuronectin; myotendinous antigen; tenascin-C isoform 14/AD1/16; glioma-associated-extracellular matrix antigen; GP; JI; HXB; GMEM; TN-C; 150-225
• Gene ID: 3371
• mRNA Refseq: NM_002160
• Protein Refseq: NP_002151
• MIM: 187380
• UniProt ID: P24821

Reviews

12/03/2020

Using TNC, the lower limit of detection of Western blot was significantly reduced.

12/30/2019

The repeatability of TNC is very good, which can reduce the error in the experiment and improve the reproducibility of the experiment.

09/19/2019

TNC were labeled very well and could be used for fluorescent labeling, etc., which was very suitable for our study.

Q&As

Is there an association between TNC protein and cardiovascular disease?

Some studies have found that TNC protein plays a role in cardiovascular diseases such as atherosclerosis, myocardial infarction, etc., and may participate in pathophysiological processes.

Which role of TNC protein in the nervous system?

TNC protein plays an important role in the development and repair of the nervous system, including neuronal migration, axon growth and synapse formation.

Are there an association between TNC protein and neurodegenerative diseases?

Some studies have found that TNC protein is associated with neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease, and may be involved in the occurrence and development of diseases.

Is there a relationship between the measurement of TNC protein and its function?

TNC protein measurement can be used for cancer diagnosis and disease prognosis, but further studies are needed to confirm a direct link with TNC protein function.

What is the relationship between TNC protein and immune regulation?

TNC protein plays a role in immune regulation, can regulate inflammatory response, promote the activation and migration of immune cells, etc.

What is the relationship between TNC protein and tissue repair?

This protein plays an important role in tissue repair, can regulate cell migration, cell proliferation, and the formation of new blood vessels, and promote tissue repair.