Recombinant Human TNFSF11, His-tagged
Cat.No. : | TNFSF11-3553H |
Product Overview : | Recombinant humanTNFSF11 protein, fused to His-tag at N-terminus, was expressed in E. coli andpurified by using conventional chromatography. |
- Specification
- Gene Information
- Related Products
Cat. No. : | TNFSF11-3553H |
Description : | TNFSF11,also known as RANKL, is a member of the tumor necrosis factor (TNF) cytokinefamily which is a ligand for osteoprotegerin and functions as a key factorfor osteoclast differentiation and activation. TNFSF11 also has a function inthe immune system, where it is expressed by T helper cells and is thought tobe involved in dendritic cell maturation. TNFSF11 is important in bonemetabolism. This natural and necessary surface- bound molecule (also known asCD254) found on osteoblasts serves to activate osteoclasts, which are the cellsinvolved in bone resorption. |
Form : | Liquid. 20mM Tris-HClbuffer (pH8.0) containing 20% glycerol, 0.1M NaCl, 1mM DTT. |
Molecular Weight : | 22.3 kDa(199 aa), confirmed by MALDI-TOF. |
Purity : | > 80%by SDS - PAGE |
Concentration : | 0.5 mg/ml(determined by Bradford assay) |
Sequences of aminoacids : | MGSSHHHHHHSSGLVPRGSH M IRAEKAMVD GSWLDLAKRS KLEAQPFAHL T INATDIPSG SHKVSLSSWYHDRGWAKISN MTFSNGKLIV NQDGFYYLYA NICFRHHETS GDLATEYLQL MVYVTKTSIK IPSSHTLMKGGSTKYWSGNS EF HFYSINVG GFFKLRSGEE ISIEVSNPSL LDPDQDATYF GAFKVRDID |
Storage : | Can bestored at +4°C short term (1-2 weeks). For long term storage, aliquot andstore at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Gene Name : | TNFSF11 tumor necrosis factor(ligand) superfamily, member 11 [ Homo sapiens ] |
Official Symbol : | TNFSF11 |
Synonyms : | TNFSF11; tumor necrosis factor (ligand)superfamily, member 11; ODF; OPGL; sOdf; CD254; OPTB2; RANKL; TRANCE;hRANKL2; tumor necrosis factor ligand superfamily member 11; osteoprotegerinligand; osteoclast differentiation factor; TNF-related activation-inducedcytokine; receptor activator of nuclear factor kappa B ligand; receptoractivator of nuclear factor kappa-B ligand; OTTHUMP00000018328;OTTHUMP00000178585 |
Gene ID : | 8600 |
mRNA Refseq : | NM_003701 |
Protein Refseq : | NP_003692 |
MIM : | 602642 |
UniProt ID : | O14788 |
Chromosome Location : | 13q14 |
Pathway : | Cytokine-cytokine receptor interaction;IL6-mediated signaling events; Osteoblast Signaling; Osteoclastdifferentiation; Rheumatoid arthritis |
Function : | cytokine activity; receptor activity; tumornecrosis factor receptor binding; tumor necrosis factor receptor superfamilybinding |
Products Types
◆ Recombinant Protein | ||
Tnfsf11-6551M | Active Recombinant Mouse Tnfsf11 Protein | +Inquiry |
TNFSF11-2025R | Recombinant Rat TNFSF11 Protein | +Inquiry |
TNFSF11-5859R | Recombinant Rat TNFSF11 Protein, His (Fc)-Avi-tagged | +Inquiry |
TNFSF11-0757H | Active Recombinant Human TNFSF11 protein(Gly64-Asp245), hFc-tagged | +Inquiry |
TNFSF11-3253H | Active Recombinant Human TNFSF11 protein(Gly 63-Asp 244), rFc-tagged | +Inquiry |
◆ Lysates | ||
TNFSF11-1093HCL | Recombinant Human TNFSF11 cell lysate | +Inquiry |
TNFSF11-1586MCL | Recombinant Mouse TNFSF11 cell lysate | +Inquiry |
TNFSF11-001CCL | Recombinant Cynomolgus TNFSF11 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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