Recombinant Human TNFSF11 Protein (Tyr69-Asp317), C-His tagged
Cat.No. : | TNFSF11-5227H |
Product Overview : | Recombinant human TNFSF11 (Tyr69-Asp317) fused with the C-terminal His tag was expressed in Mammalian cells. |
- Specification
- Gene Information
- Related Products
Description : | Receptor activator of nuclear factor kappa-B ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is known as a type II membrane protein and is a member of the tumor necrosis factor (TNF) superfamily. RANKL, through its ability to stimulate osteoclast formation and activity, is a critical mediator of bone resorption and overall bone density. Some findings also suggestion some cancer cells, particularly prostate cancer cells, can activate an increase in bone remodeling and ultimately increase overall bone production.[17] This increase in bone remodeling and bone production increases the overall growth of bone metastasizes. The overall control of bone remodeling is regulated by the binding of RANKL with its receptor or its decoy receptor, respectively, RANK and OPG. |
Source : | Mammalian cells |
Species : | Human |
Tag : | C-His |
Form : | Lyophilized powder/frozen liquid |
Molecular Mass : | 27.39 kDa |
Protein Length : | Tyr69-Asp317 |
Endotoxin : | < 1.0 EU/μg of the protein as determined by the LAL method. |
Purity : | >90% as determined by SDS-PAGE. |
Notes : | For research use only. |
Storage : | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt. |
Storage Buffer : | Supplied as solution form in PBS or lyophilized from PBS. |
Reconstitution : | Reconstitute in sterile water for a stock solution. |
Shipping : | They are shipped out with dry ice/blue ice unless customers require otherwise. |
Gene Name : | TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 [ Homo sapiens (human) ] |
Official Symbol : | TNFSF11 |
Synonyms : | TNFSF11; tumor necrosis factor (ligand) superfamily, member 11; tumor necrosis factor ligand superfamily member 11; CD254; ODF; OPGL; RANKL; TRANCE; osteoprotegerin ligand; osteoclast differentiation factor; TNF-related activation-induced cytokine; receptor activator of nuclear factor kappa B ligand; receptor activator of nuclear factor kappa-B ligand; sOdf; OPTB2; hRANKL2; |
Gene ID : | 8600 |
mRNA Refseq : | NM_003701 |
Protein Refseq : | NP_003692 |
MIM : | 602642 |
UniProt ID : | O14788 |
Products Types
◆ Recombinant Protein | ||
TNFSF11-0757H | Active Recombinant Human TNFSF11 protein(Gly64-Asp245), hFc-tagged | +Inquiry |
TNFSF11-683M | Recombinant Mouse TNFSF11 Protein | +Inquiry |
TNFSF11-459H | Recombinant Human TNFSF11 Protein, His-tagged | +Inquiry |
TNFSF11-316H | Recombinant Active Human TNFSF11 Protein, His-tagged(C-ter) | +Inquiry |
TNFSF11-255M | Active Recombinant Mouse TNFSF11 Protein | +Inquiry |
◆ Lysates | ||
TNFSF11-998HCL | Recombinant Human TNFSF11 cell lysate | +Inquiry |
TNFSF11-001CCL | Recombinant Cynomolgus TNFSF11 cell lysate | +Inquiry |
TNFSF11-1093HCL | Recombinant Human TNFSF11 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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